this study was designed to investigate the therapeutic effects of saffron (crocus sativus l) and its main constituent crocin on neuropathic pain behavioral responses induced by chronic constriction injury (cci) in rats. adult male wistar rats (200 to 250 g) were randomly assigned into 5 groups: sham + saline, cci + saline, cci+ saffron (30 mg/kg), cci +crocin (15 mg/kg) and cci + crocin (30 mg/...

background: saffron is the dried stigmata of the flowers of saffron (crocus sativus l., iridaceae). saffron and its major active constituents, crocin (crocetin glycoside), crocetin and safranal, have a variety of pharmacological effects including high antioxidant properties and crocetin has insulin sensitizing effect possibly due to its antioxidant activity. oral crocin is not absorbed and is h...

the acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. for subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. the intraperitoneal ld50 values of safranal were 1.48 ml/kg in male mice, 1.88 ml/kg in female mice and 1.50 ml/kg in male rats. oral ld50 values were ...

objective(s): crocin is the chemical ingredient primarily responsible for the color of saffron. it has different pharmacological effects such as antioxidant, anticancer and memory improving activities. crocin tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. materials and methods: the study was a randomized, double-blind, placebo-controlled design consis...