a randomized, double-blind, crossover trial was designed to compare the acute effects of combivent and salbutamol on spirometric parameters in patients with moderate to severe asthma. nineteen patients with a mean baseline forced expiratory volume in 1 sec. (fev]) less than 65% predicted, were randomized on two separate days to receive two puffs of salbutamol (200 µg) or two puffs of combivent ...

A new method for determination of salbutamol sulfate has been developed using poly(4-amino-3-hydroxynaphthalene sulfonic acid/GCE. Cyclic voltammetric investigation of the electrochemical behavior of salbutamol sulfate at the polymer modified glassy carbon unveiled electrocatalytic activity of the modifier towards irreversible oxidation of salbutamol sulfate. Dependence of peak current predomin...

OBJECTIVE To evaluate the efficacy of inhaled salbutamol, a beta-2 adrenergic agonist, for the treatment of transient tachypnea of the newborn (TTN) and to determine whether inhaled salbutamol is safe in newborn infants. STUDY DESIGN Inhaled salbutamol or normal saline solution was administered to 54 infants with gestational ages ranging from 34 to 39 weeks and TTN. The response to salbutamol...

  Objective(s): It has been suggested that the efficiency of dry poder inhaler (DPI) is generally low. Therefore, the aim of the present research work was to use the solvent treatment of the carrier in DPIformulations to see the possibility of inducing desirable characteristics.   Materials and Methods: Lactose sieve fractions of 63-90 μm were submerged in ethanol or 80% v/v etha...

Abstract In the present case with primary pseudohypoaldosteronism, severe hypekalemia was treated with salbutamol inhalation in acute phase. Transcellular hypokalemic effect of salbutamol is related to the activation of Na-K pump on the cell membrane. Although use of salbutamol inhalation in hyperkalemia was previously described, it has not been widely used. The administration of salbutamol by ...

inhalational insulin was withdrawn from the market due to its potential to produce airway hyper-reactivity and bronchoconstriction. so the present study was designed to explore the acute effects of insulin on airway reactivity of guinea pigs and protective effects of salbutamol and beclomethasone against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pi...

The efficacy of ipratropium and salbutamol was determined in 117 patients with acute asthma who presented to an emergency department to determine whether the order of administration of the two agents affects the improvement in peak flow rates. Patients were given two nebulized treatments at an interval of one hour in a randomized, double-blind design. They received either 5 mg nebulized salbuta...

The Department of Health estimates that asthma including 10 major causes morbidity and mortality in the hospital. Asthma is a chronic respiratory disease becoming serious health problem many countries around world. Drugs used treatment exacerbations salbutamol aminophylline. such as aminophylline can cause ADR (Adverse Drug Reaction) form tremor with sign involuntary shaking part hand. This res...

In recent years, co-milling of active pharmaceutical ingredients (APIs) with excipients is being investigated as a promising technique to improve desired properties such as solubility and dissolution profiles, bioavailability, aerosolization and physical stability. Traditionally, excipients are simply blended into a drug formulation to improve the manufacturability or product quality, e.g. to i...