BACKGROUND Many patients with refractory or relapsed gastric cancer after first-line chemotherapy have received salvage chemotherapy in routine clinical practice. However, there was no evidence to support this treatment until recent phase III trials demonstrated substantial prolongation of overall survival. Therefore, we conducted a meta-analysis of these trials and investigated whether second-...

BACKGROUND & OBJECTIVE The prognosis of relapsed or refractory aggressive non-Hodgkin's lymphoma (NHL) after front-line therapy remains poor. The development of more effective and less toxic salvage regimens remains a major challenge. Gemcitabine is effective in treating lymphoma and, when combined with cisplatin, is effective for some solid tumors. This study was to evaluate the efficacy of GD...

Pineoblastomas are malignant embryonal tumours that are classified as suprasellar primitive neuroectodermal tumours. Incidence of pineoblastoma is approximately 0.1% to 0.3% of histogically verified primary malignant brain tumours. This case report concerns a 19-year-old male with a mass lesion in an area posterior to third ventricle, which was diagnosed as pineoblastoma. He achieved complete r...

The prognosis of patients with metastatic or recurrent squamous cell carcinoma of the head and neck region (SCCHN) is generally poor, with a median survival of 5-9 months, depending on patient and disease-related factors. Selected patients with good performance status and locally recurrent disease may benefit from surgical salvage and/ or re-irradiation. For most patients with metastatic or adv...

BACKGROUND Glioblastoma is usually diagnosed around the age of 60-70 years. Patients older than 65 years are frequently described as "elderly". Several trials with monotherapy have established treatment regimens that offer therapies with reduced side effects but reduced efficacy. We analysed the outcome of elderly glioblastoma patients treated at our facility. METHODS We performed a retrospec...

Introduction Musculoskeletal oncology is a rapidly evolving field in orthopaedic surgery and surgical management for patients with osteosarcoma has progressed significantly over the past three decades. Due to advances in neoadjuvant treatment, imaging modalities, surgical techniques and material and prosthesis designs, amputation is no longer considered as standard of care in most cases. Litera...

Over the last few decades, advances in immunochemotherapy have led to dramatic improvement in the prognosis of non-Hodgkin's lymphoma (NHL). Despite these advances, relapsed and refractory disease represents a major treatment challenge. For both aggressive and indolent subtypes of NHL, there is no standard of care for salvage regimens, with prognosis after relapse remaining relatively poor. Nev...