BACKGROUND To clarify the clinical outcomes of two dose schedule of stereotactic body radiotherapy (SBRT) for stage I non-small cell lung cancer (NSCLC) using a real-time tumor-tracking radiation therapy (RTRT) system in single institution. METHODS Using a superposition algorithm, we administered 48 Gy in 4 fractions at the isocenter in 2005-2006 and 40 Gy in 4 fractions to the 95% volume of ...

BACKGROUND Stereotactic body radiotherapy (SBRT) for non-small cell lung cancer (NSCLC) is primarily a treatment option for medically inoperable patients, who are often elderly. However, few studies report the effects of SBRT in elderly patients. Thus, we retrospectively analyzed clinical outcomes and feasibility following treatment of very elderly patients (age ≥ 85 years) with stage Ι NSCLC a...

BACKGROUND The purpose of this study was to assess stereotactic body radiation therapy (SBRT) results and toxicity for stage I non-small cell lung cancer patients with low performance status and severe comorbidity. PATIENTS AND METHODS From September 2008 to April 2010, 36 patients with 38 lesions were treated with hypofractionated SBRT. All except one were medically inoperable, had low perfo...

BACKGROUND Patients treated with stereotactic body radiation therapy (SBRT) for early-stage non-small-cell lung cancer (NSCLC) are subject to locoregional and distant recurrence, as well as the formation of second primary lung cancers (SPLCs). The optimal surveillance regimen for patients treated with SBRT for early-stage NSCLC remains unclear; we therefore investigated the posttreatment recurr...

The motion management in stereotactic body radiation therapy (SBRT) is a key to success for a SBRT program, and still an on-going challenging task. A major factor is that moving structures behave differently than standing structures when examined by imaging modalities, and thus require special considerations and employments. Understanding the motion effects to these different imaging processes ...

BackgroundThe study aims to identify the risk factors and develop a model for predicting grade ≥ 2 radiation pneumonitis (RP) lung cancer patients treated with stereotactic body therapy (SBRT).Materials MethodsClinical data, dosimetric laboratory biomarkers from 186 SBRT were collected. Univariate multivariate logistic regression performed determine predictive RP. Three models developed by usin...

IntroductionData is limited on radiation induced lung toxicities (RILT) after multiple courses of stereotactic body therapy (SBRT). We herein analyze a large cohort patients to explore the clinical and dosimetric risk factors associated with RILT in such settings.MethodsA single institutional database treated SBRT between January 2014 December 2019 was analyzed. Grade 2 or higher (G2+RILT) last...

Purpose: To evaluate the current status of stereotactic body radiotherapy (SBRT) for early staged non-small cell lung cancer (NSCLC) at main cancer hospitals in China. Methods and Materials: The questionnaire was sent by mail and email to 21 hospitals, which include the patient enrollment, treatment technique, dose and fractionation, quality control, disease control and side effects. Results: N...

This study evaluated the extent of improvement in dose predication accuracy achieved by the Fast Monte Carlo algorithm (MC) compared to the Ray Tracing algorithm (RAT) in stereotactic body radiotherapy (SBRT) of non-small cell lung cancer (NSCLC), and how their differences were influenced by the tumor site and size. Thirty-three NSCLC patients treated with SBRT by CyberKnife in 2011 were recrui...

Genomics has not yet been integrated into the clinical practice of Radiation Oncology. Liquid biopsy is a non-invasive tool based on study circulating tumor DNA (ctDNA), mainly applied to advanced cancer patients treated with chemotherapy. This work assesses utility liquid in early-stage/oligometastatic undergoing stereotactic body radiation therapy (SBRT). Next-generation sequencing (NGS) geno...