The rate of ethanol metabolism was determined for 20 alcoholics during ajiemoon and evening drinking sessions on two consecutive days. Alcoholics demonstrated a faster rate of ethanol metabolism in the evening as compared to the afternoon, suggesting a circadian variation in the rate of ethanol metabolism. Previous drinking on the first day appeared to increase the rate of ethanol metabolism on...

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer by 2030, and the overall 5-year survival rate is currently less than 7%. Cancer cells frequently exhibit reprogramming of their metabolic activity. It is increasingly recognized that aberrant de novo lipid synthesis and reprogrammed lipid metabolism are both associated with the development and progression...

1 Department of Endocrinology and Metabolism, Osaka University, Suita, Japan 2 Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan 3 National Hospital Organization Osaka National Hospital, Osaka, Japan 4 Department of Cardiology and Internal Medicine, Kitasato University, Sagamihara, Japan 5 Department of Medicine, Shiga University of Medical Science, Ohtsu, Japan 6 De...

An ensemble of genetic networks that describe how the model fungal system, Neurospora crassa, utilizes quinic acid (QA) as a sole carbon source has been identified previously. A genetic network for QA metabolism involves the genes, qa-1F and qa-1S, that encode a transcriptional activator and repressor, respectively and structural genes, qa-2, qa-3, qa-4, qa-x, and qa-y. By a series of 4 separat...

1Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha 410011, China 2Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, Stanford, CA 94305, USA 3Departments of Cardiothoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China 4Warsaw University of Life Sciences, 02-787 W...

Daily water metabolism of 21 patients was studied for 3 days after intracardiac surgery and whole-body perfusion. The average obligatory water losses of these patients were approximatelv 500, 750, and 750 ml. per 1\I3 of body surface per day on the first, second, and third postoperative day, respectively. A simple system, which combines knowledge of the estimated postoperative water requirement...

CONTENTS Introduction The Search for a “Unit of Culture” The Laws of Evolution Applied to the Noosphere Autopoiesis in Noosphere Holons Agreements and Relationships—Noosphere Organisms From Meaning to Value Beauty, Truth, and Goodness—The Primary Values The Directions of Evolution Tripartite Evolution The Perfection Directions Applications of the Theory for Noosphere Evolution Value Nourishment...

Temperature and aeration shifts were used to perturb steady-state continuous cultures to determine the effects of ethanol on xylose metabolism by Candida shehatae. The accumulation of ethanol exerted a delayed inhibitory effect on the specific rate of substrate utilization. A second effect was also observed in which the specific rate of xylitol production increased at the expense of the specifi...

1 Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China 2 Clinical Research, Diabetes and Endocrinology, Merck Research Laboratories, 126 East Lincoln Avenue, RY34B-148, Rahway, NJ 07065-0900, USA 3Department of Nutritional Science, Rutgers University, New Brunswick, NJ 08901, USA 4Division of Endocrinology, Metabolism an...