OBJECTIVE To quantify and characterise missed opportunities for earlier HIV diagnosis in patients diagnosed with advanced HIV. DESIGN A retrospective observational cohort study. SETTING A central tertiary medical centre in Israel. MEASURES The proportion of patients with advanced HIV, the proportion of missed opportunities to diagnose them earlier, and the rate of clinical indicator disea...

The objective of this study was to assess the role performance among KOSPEN community health volunteer in Kuching district and its associated factors. This was a cross-sectional study, conducted in 21 localities in Kuching with a total of 210 respondents. Data were collected using validated interviewer-administered questionnaires and analyzed using SPSS version 22.0. The respondents comprised 5...

This paper reports on a case study of the teacher's role as facilitator in computer-supported collaborative learning (CSCL) settings in science. In naturalistic classroom settings, the teacher most often acts as an important resource and provides various forms of guidance during students' learning activities. Few studies, however, have focused on the role of teacher intervention in CSCL setting...

Primary and secondary immunodeficiency disorders are a diverse group of illnesses resulting from one or more abnormalities of the immune system. The clinical manifestations include increased susceptibility to infection and an increased risk for autoimmune disease and malignancy. Primary immune deficiency (PID) diseases are a group of serious disorders arising from an intrinsic defect in the imm...

Background: Primary (PID) or secondary (SID) immunodeficiencies are diseases caused by quantitative and/or functional alterations of the different mechanisms involved in innate and adaptive immune response. This economic evaluation was conducted to compare cost treatment HYQVIA® (hyaluronidase-facilitated subcutaneous infusion immunoglobulin, fSCIG) compared intravenous immunoglobulin (IVIG) (S...

Heterologous prime/boost regimens are AIDS vaccine candidates because of their potential for inducing cellular immune responses. Here, we have developed a prime/boost regimen leading to rapid control of highly pathogenic immunodeficiency virus infection in macaques. The strategy, priming by an env and nef deletion-containing simian-human immunodeficiency virus (SHIV) proviral DNA followed by a ...