We present evidence that regulation of dense-core secretory granule biogenesis and hormone secretion in endocrine cells is dependent on chromogranin A (CGA). Downregulation of CGA expression in a neuroendocrine cell line, PC12, by antisense RNAs led to profound loss of dense-core secretory granules, impairment of regulated secretion of a transfected prohormone, and reduction of secretory granul...

Secretory vesic1es from adrenal medulla contain catecholamines, nuc1eotides and proteins, all of which are released into the extracellular fluid during exocytosis. Adrenal medullary secretory vesic1es also contain high concentrations of Ca'+ [1]. The mechanism of the aecumulation of Ca 2+ into the vesicles is largely unknown and the experimental data eoncerning the uptake of Ca'+ into isolated ...

The secretory pathway is responsible for the synthesis, folding, and delivery of a diverse array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum (ER), which is charged with the tasks of correctly integrating nascent proteins and ensuring correct post-translational modification and folding. Once ready for forward traffic, proteins are captured into ER-derive...

Abstract Extracellular matrix protein-1 (ECM1) promotes tumorigenesis in multiple organs but the mechanisms associated to ECM1 isoform subtypes have yet be clarified. We report this study that secretory ECM1a induces through GPR motif binding integrin ?X?2 and activation of AKT/FAK/Rho/cytoskeleton signaling. The ATP cassette subfamily G member 1 (ABCG1) transduces ECM1a-integrin interactive si...

background: helicobacter pylori may cause many gastrointestinal problems in developing countries such as iran. we aimed to analyze the cost- effectiveness and cost- utility of the test-and-treat and empirical treatment strategies in managing helicobacter pylori infection.            methods: this was a markov based economic evaluation. effectiveness was defined as the symptoms free numbers and ...

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Address correspondence to Gillian M. Griffiths, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. Tel.: (44) 1865-275571. Fax: (44) 1865-275515. E-mail: gillian.griffiths @path.ox.ac.uk T HE process of regulated secretion (reviewed in Bugress and Kelly, 1987) is critical for the correct biological functioning of many different cells of the immune ...

Intercellular communication is fundamental in many biological processes involved in cell growth, differentiation, development, and reproduction of living organisms and secretory proteins are among the most important messengers in this network of information. The vast majority of extracellular proteins are exported from cells by the endoplasmic reticulum/Golgi-dependent secretory pathway. Howeve...