How congenital defects causing genome instability can result in the pleiotropic symptoms reminiscent of aging but in a segmental and accelerated fashion remains largely unknown. Most segmental progerias are associated with accelerated fibroblast senescence, suggesting that cellular senescence is a likely contributing mechanism. Contrary to expectations, neither accelerated senescence nor acute ...

OBJECTIVE To determine if medio-lateral motion of the head, trunk, or pelvis demonstrates dynamic stability as well as whole-body center of mass during obstructed walking. DESIGN Group comparison of two elderly populations using whole-body motion analysis. BACKGROUND Detection of imbalance through analysis of center of mass motion is commonly adopted, requiring three-dimensional reconstruct...

STUDY DESIGN Four patients had C2-3 vertebral fusion and radiologically demonstrated cord compression at C3-4 level related to disc bulge with or without association of osteophytes and C1-2 posterior facetal dislocation. The outcome of treatment by atlantoaxial and subaxial facetal fixation is discussed. PURPOSE The article evaluates the significance of atlantoaxial facetal instability in cas...

The dorsal radiocarpal ligament (DRCL) has been implicated in both volar and dorsal intercalated segmental instabilities and has a role in midcarpal instability. Tears of the DRCL are more common than previously suspected. They are best seen through a volar radial portal and are amenable to arthroscopic repair. DRCL tears appear to be part of a spectrum of radialand ulnar-sided carpal instabili...

BACKGROUND The long-term outcome after lumbar microdiscectomy (LMD) may be affected by low back pain (LBP) and segmental instability, the determinants of which remain unclear. We sought to analyze the interaction between clinical, functional, and radiological variables and their impact on patient outcome. METHODS All patients who underwent LMD in 2004-2005 were invited to participate in this ...

Genetic instability is a hallmark of cancer. Most tumors show complex patterns of translocations, amplifications, and deletions, which have occupied scientists for decades. A specific problem arises in carcinomas with a genetic defect termed chromosomal instability; these solid tumors undergo gains and losses of entire chromosomes, as well as segmental defects caused by chromosome breaks. To da...

BACKGROUND Excessive lumbar vertebrae translation and rotation in sagittal plane has been attributed as an associated factor of lumbar segmental instability (LSI) and low back pain (LBP). Reduction of these abnormalities improves back pain. The aim of this study was to investigate the effect of core stability exercise on the translation and rotation of lumbar vertebrae in sagittal plane in pati...

this paper presents a model of a catchment area in northwest of iran. the researchers have studied ajichai basin which is located in the east part of orumiyeh lake, located at the longitude of 47 52’ e to 45 32’ e and the latitude of 37 26’ n to 38 30’ n. the researchers have chosen the data from tabriz upper air station which is the only one in the area. the research data are seven instability...