The way to overcome current limitations in the generation of glucose-responsive insulin-producing cells is selective enrichment of the number of definitive endoderm (DE) progenitor cells. Sox17 is the marker of mesendoderm and definitive endoderm. The aim of the present research was to study the potential of Sox17 knock-in CGR8 mouse embryonic stem (ES) cells to differentiate into insulin produ...

The molecular determinants that govern selective ligand binding to the rat D(4) dopamine receptor were investigated by substituting D(2) dopamine receptor sequences into a D(4) dopamine receptor background. The resulting mutant D(4) dopamine receptors were then screened with a panel of 10 selective and nonselective ligands, which included two allosteric modulators as sensitive measures of prote...

The use of secondary interactions between substrates and catalysts is a promising strategy to discover selective transition metal for atom-economy C−H bond functionalization. most powerful are found via trial-and-error screening due the low association constants substrate catalyst in which small stereo-electronic modifications within them can lead very different reactivities. To circumvent thes...

Orbital-selective phenomena in mutliorbital systems have received much attention due to their uniqueness as well possible connections other phenomena. As orbital-selectiveness is mostly related the crystal structure, finding a new control parameter than structure would be of significant importance. Here we report discovery an orbital-selective doping effect ${\mathrm{Sr}}_{2}{\mathrm{Ru}}_{1\en...

The design of molecularly imprinted polymers (MIPs) for the specific binding hydrophobic molecules (mitotane) was investigated by considering monomers and cross-linking agents with variable character, methyl methacrylate, butyl methacrylate lauryl as functional monomers, ethylene glycol dimethacrylate 1,6-hexanediol agents. MIPs were bound to a porous silica support means radical transfer react...

Objective(s): Somatostatin receptor-positive neuroendocrine tumors have been targeted using various peptide analogs radiolabeled with therapeutic radionuclides for years. The better biomedical properties of radioantagonists as higher tumor uptake make these radioligands more attractive than agonists for somatostatin receptor-targeted radionuclide therapy. In this study...