The weathering of selenium-rich rocks or anthropogenic activities such as mining smelting can release selenium into the environment, posing a significant environmental risk. increased monitoring and enforcement regulations have resulted in protocols to efficiently measure treat water effluent water. principal aqueous forms inorganic are selenite (Se(IV)) selenate (Se(VI)). Selenate, due its oxy...

INTRODUCTION Sepsis is associated with the generation of oxygen free radicals and (lacking) decreased selenium plasma concentrations. High doses of sodium selenite might reduce inflammation by a direct pro-oxidative effect and may increase antioxidant cell capacities by selenium incorporation into selenoenzymes. We investigated the effects of a continuous administration of high doses of seleniu...

Doxorubicin is an effective drug against breast cancer. However, the favorable therapeutic response to doxorubicin is often associated with severe toxicity. The present research was aimed at developing a strategy of increasing doxorubicin sensitivity so that lower doses may be used without compromising efficacy. The MCF-7 human breast cancer cell line currently in use in our laboratory did not ...

Hepatotoxic effect of 5-Fluourouracil (5-FU) can deprive cancer patients of maximum therapeutic benefits. Aim: This study assessed the ability of selenium (Se) to protect against hepatotoxicity induced by 5-FU in rats. Forty adult albino rats were groups and used. Rats in group A (control) were treated intraperitoneally (ip) with 0.2ml of normal saline daily for 5 days. Rats in groups B1-B3 wer...

The siderophore of Pseudomonas stutzeri KC, pyridine-2,6-bis(thiocarboxylic acid) (pdtc), is shown to detoxify selenium and tellurium oxyanions in bacterial cultures. A mechanism for pdtc's detoxification of tellurite and selenite is proposed. The mechanism is based upon determination using mass spectrometry and energy-dispersive X-ray spectrometry of the chemical structures of compounds formed...

The objective of this paper is to provide an analysis of particulate metal emissions in the USA. The analysis will identify natural and industrial sources, environmental standards, emission trends, and controls of particulate emissions. Since the majority of airborne metal emissions originate from metal industries and electric utility facilities, environmental and worker assessments of exposure...

Selenium oxyanions are toxic to living organisms at excessive levels. The accumulation of selenium in certain environments requires the development of efficient detoxification processes. In this study, we demonstrated the ability of two Anaeromyxobacter dehalogenans strains to readily convert toxic Se(IV) to less toxic insoluble Se(0), as confirmed by energy-dispersive X-ray spectrometry and X-...

Research regarding the nutritional importance of selenium (Se) has changed markedly over the last 75 years. In the 1930's Se was identified as the toxic agent causing alkali disease in animals. In the 1940's and early 1950's research was conducted to identify the specific seleno-compounds causing toxicity and to develop prophylactic and treatment schemes for selenium toxicity. Selenium research...

Abstract Selenium containing drugs like selenomethionine, selenocystine, selenourea and methylseleninic acid are reported to exhibit potential anticancer effect. However, these may exert adverse effects when used over a prolonged period. Little is known about the interaction of selenium with vital erythroid protein hemoglobin. In this work comparative study organo-selenium hemoglobin heme moiet...