Adenocarcinoma of prostate metastasizing to testis is a rare occurrence and is incidentally detected in orchiectomy specimens. The pattern of metastasis may mimic a primary neoplasm of testis like a seminoma or lymphoma and pose a diagnostic difficulty for the pathologist. A rare case of bilateral testicular metastasis of prostatic adenocarcinoma is presented wherein the metastatic cells expres...

Reaction to Yadav S et al: Invalid presentation of bilateral synchronous spermatocytic seminoma Kanika Sharma, Piyush Kalakoti, Kush Ohri, Suman Sahu, Sreenivas Veeranki Rural Medical College, Pravara Institute of Medical Sciences, Loni, MH 413736, India,Pushpanjali Crosslay Hospital, Ghaziabad, UP 201012, India, University of Texas Medical Branch, Galveston, TX, United States of America Corres...

AIM To report long term oncologic outcomes after adjuvant radiotherapy (RT) for stage I seminoma. METHOD We reviewed the complete data set for all patients treated at our institute between 1988 and 2005 for stage I seminoma with adjuvant RT after radical orchiectomy . RESULTS A total of 85 patients were included. The median follow-up was 15 years. The 20-year overall survival (OS) and relap...

Human endogenous retrovirus K10 (HERV-K10) env and gag expression has been detected in placenta, embryonic tissue, and cell lines. By transfection, these sequences have been expressed in insect cells and developed into serological assays, revealing HERV-K10 antibodies in patients with testicular cancer. Patients with AIDS are at an increased risk for testicular cancer and frequently reactivate ...

Primary mediastinal seminoma is an uncommon tumor usually located in the anterior mediastinum. The majority of cases occur in young males. We report here an extremely rare case of a 69-year-old male with primary seminoma in the middle mediastinum. The patient had no complaints, but an abnormal shadow was seen in a routine chest X-ray. We performed a tumorectomy in the middle mediastinum, a thym...

We report a histologically pure stage 1 seminoma with an elevated human chorionic gonadotropin (hCG). A 38 year-old man was referred for the evaluation of the left testicular swelling. He showed an elevated serum hCG level of 25,265 mIU/ml with normal a fetoprotein and lactate dehydrogenase. Imaging showed heterogeneous tumor without any metastatic lesions. We conducted 4 courses of chemotherap...

226 Background: To better understand the impact of RT on mortality, we analyzed long-term survival and patterns of excess mortality in men with stage I seminoma. METHODS 9,045 men with stage I seminoma were identified in the Surveillance Epidemiology and End Results database. Time to testicular-cancer mortality (TCM), death from second malignancy (SM), cardiovascular mortality (CVM) or suicid...

introduction: Seminoma comprises ~50% of testicular germ cell tumors. Renal metastases are infrequent and are usually diagnosed at necropsy. Clinical case: A 24-year-old male with a history of left radical orchiectomy and adjuvant radiotherapy due to classic seminoma (stage I) showed elevated levels of b-human chorionic gonadotropin and lactate dehydrogenase during the 11-month follow-up. Compu...

Cryptorchidism is the most common predisposing factor in the development of testicular germ cell tumors. Seminoma is the most common malignancy developing in a cryptorchid testis, usually has lymphatic but rarely hematogenous metastasis. The Urinary Bladder is an extremely rare site of metastasis of seminoma metastasis. A 29-year-old male patient presented to us with a history of infertility an...

Few cases of synchronous bilateral stage I seminomas have been reported in the world literature. We present a case of bilateral synchronous testicular seminoma, the current literature on the management of stage I seminoma, and the implications for radiotherapy. A forty-year-old man presented with synchronous bilateral classical seminomas, both stage IA. After undergoing bilateral inguinal orchi...