Evidence suggests the existence of multiple interactions between dopamine, glutamate and nitric oxide (NO) in brain structures associated with psychomotor stimulation. The present study was undertaken to investigate the effect of the relatively selective inhibitor of the neuronal nitric oxide synthase (NOS) isoform, 7-nitroindazole (7-NI), on the development of sensitization to the locomotor st...

background burn pain is recognized as being maximal during therapeutic procedures, and wound debridement can be more painful than the burn injury itself. uncontrolled acute burn pain increases the stress response and the incidence of chronic pain and associated depression. although opiates are excellent analgesics, they do not effectively prevent central sensitization to pain. the anticonvulsan...

In this work, stabilized f-ZrO 2 ceramic samples with the compositions of (Zr 0.82 Y 0.09 Eu )O 1.91 , Tb and 0.045 were studied. The elemental composition was studied by electron probe microanalysis, luminescent properties local cathodoluminescence (CL). An analysis 3+ CL spectra confirmed stabilization cubic phase in ceramics at room temperature. study obtained spectra, 5 D 4 - 7 F band lumin...

The peripheral mechanism of hyperalgesia is considered to be the result of nociceptor sensitization. As possible agents causing nociceptor sensitization, bradykinin, histamine, prostaglandin (PG)s, protons and nerve growth factor are evaluated with respect to their release into the injured tissue, their sensitizing potencies. Whether blocking these agents suppresses sensitization was also evalu...

The aim of this study was to define the frequency and determinants of pregnancy-induced child-specific sensitization shortly after full-term delivery using sensitive single HLA-antigen beads (SAB) and high resolution HLA-typing of the mothers and their children (n = 301). A positive SAB result was defined by a background normalized ratio >1 or a mean fluorescence intensity (MFI) >300, >500 and ...

BACKGROUND The prevalence of sensitization and allergic disease has increased significantly worldwide. The aim of the "Aalst Allergy Study" was to document prevalences of sensitization and allergic symptoms, and to evaluate the effect of personal and environmental influences on these prevalences in an unbiased Belgian pediatric population. METHODS A cross-sectional study was performed in an u...

Respiratory virus infections can trigger exacerbations of asthma and may also contribute to allergic sensitization to aeroallergens and the development of asthma. Conversely, atopy may predispose to more severe virus-induced airway disease. The animal models reviewed in this article support the hypothesis that respiratory virus infections can promote allergic sensitization and the development o...

Repeated exposure to nicotine increases psychomotor activity. Long-lasting neural plasticity changes that contribute to the nicotine-induced development of locomotor sensitization have been identified. The mammalian target of rapamycin complex 1 (mTORC1) signalling pathway is involved in regulating the neuroplasticity of the central nervous system. In this study, we examined the role of mTORC1 ...