Background: Sepsis, a systemic inflammatory response to infection, resulting in organ failure and death. Pathogenic microbial agents trigger cascades of events in sepsis by stimulating the host’s immune system. Macrophages require surface receptors to present pathogenic molecule to Toll-like receptors (TLRs) to be activated and release proinflammatory cytokines such as tumour necrosis factor (T...

Background: Sepsis is one of the most common admission-diagnosis in intensive care unit (ICU). It associated with rapid organ dysfunction increased mortality. Different scoring systems {e.g. Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score, systemic inflammatory response syndrome (SIRS) criteria} are commonly used to identify and predict prognosis sepsis ICU at present. The obj...

INTRODUCTION The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis. METHODS We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs49867...

Blockade of the CXC chemokine receptor 3 (CXCR3) attenuates inflammation and improves survival in a murine model of near lethal polymicrobial sepsis. However, given the multitude of cellular responses and inflammatory mediators that orchestrate sepsis syndrome, more detailed investigations will be required before a complete understanding of the mechanism(s) of CXCR3 blockade and its therapeutic...

Aims: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious severe cutaneous adverse reactions with high mortality and morbidity induced by medications. In this cross sectional study, we investigated, suspected drugs, and potential treatments of SJS/TEN. Methods: A cross- sectional descriptive study was conducted on 60 patients admitted with a diagnosis of Stevens-Jo...

Background: Sepsis is a highly complex and fatal syndrome, considered to be the main cause of death in intensive care unit. Early diagnosis beneficial reduce mortality improve prognosis patients. Therefore, we look forward finding cheap fast diagnostic criteria quickly assess patient’s condition. Methods: Our study enrolled 499 patients our hospital from January 2020, 96 healthy cases same peri...