The 2009 pandemic strain of H1N1 influenza was back in Canada this year, despite an effective vaccine and very little mutation in the virus, researchers say. Instead, they point to a low level of seroprotection in adults aged 40 to 65 as the likely culprit. Lack of previous exposure and of vaccination have probably combined to create a “pocket of residual susceptibility,” says Dr. Danuta Skowro...

background: for healthcare workers, sometimes the conventional hepatitis-b virus (hbv) vaccination schedule might not provide seroconversion rapidly enough. the aim of this study was to compare the efficacy of conventional hbv vaccination with an accelerated schedule (days 0-1-21). normal 0 false false false en-us x-none ar-sa materials and methods: in this randomized clinical trial, 161 health...

In a sample of originally 430 healthy adults (18-84 years of age) with documented basic and booster immunization against tick borne encephalitis, cumulative seroprotection rates 8 (n=178) and 10 years (n=183) after the last booster dose were 86.8% and 77.3% according to the neutralization test, respectively. In subjects aged 50 years and older, antibody titers were significantly lower compared ...

BACKGROUND Hepatitis B Virus (HBV) infection is an important public health problem that requires high priority efforts towards prevention and control. Active immunization is the single most important and effective preventive measure against HBV infection. As a protective measure, Ghana introduced the mass immunization program against hepatitis B infection in children in 2002 in her Expanded Pro...

OBJECTIVES To determine the safety of and immunogenicity induced by A/H1N1 influenza vaccination in patients with systemic lupus erythematosus (SLE). RESEARCH DESIGN AND METHODS The study population comprised 21 SLE patients and 15 healthy control subjects who underwent split-virion, inactivated monovalent A/H1N1 vaccination between December 2009 and January 2010. Sera were obtained before, t...

hepatitis c virus (hcv) infection is highly prevalent in thalassemic patients, and this may decrease the serum antibody response to hepatitis b virus (hbv) vaccine. there is also some alteration of the immune system in multi-transfused thalassemic patients, as a consequence of iron overload. we investigated whether hcy infection may reduce the effectiveness of hby vaccine in multi - transfused ...

Background: Several adjuvants have been evaluated for vaccine formulations but alu-minum salts will continue to be used for many years due to their safety, low cost and adjuvanticity with different antigens. Two commonly used aluminum adjuvants, alumi-num hydroxide and aluminum phosphate have different adjuvanticity properties. Com-mercial recombinant protein hepatitis B vaccines containing alu...

     Thimerosal, which is approximately 50% mercury by weight is a preservative widely used in vaccines since the 1930’s. It meets the requirements for a preservative as set forth by Pharmacopeia challenge test and has been shown to be effective against a broad spectrum of pathogens. In July 1999, the Public Health Service agencies and vaccine manufacturers agreed that thimerosal should be redu...