Although personalized medicine is an ideal concept, there remains little training or discussion to its applicability for the primary care provider. Psychiatric, cardiac, gastrointestinal, and pain are common complaints/conditions seen in care, treatment options have genomic implications. This article provides experienced clinician with background, clinical utility, of pharmacogenetics medicatio...

The use of antidepressant medication in the general population has increased considerably in past decades, in particular the use of selective serotonin reuptake inhibitors (SSRIs). This increase in SSRI use may be explained by a broadened indication of SSRI, a different adverse effect profile, and a lower toxicity compared with classic tricyclic antidepressants. Yet, despite a more favorable ad...

Editor—Gunnell et al’s report on suicide risk with selective serotonin reuptake inhibitors (SSRIs) raises several issues. Firstly, clinicians have observed that the first weeks of treatment of severe depression with an antidepressant are accompanied by a higher risk of suicide because of a drug induced motor disinhibition that is not yet accompanied by mood improvement. Secondly, the authors’ f...

The paper by Bérard et al. [1] ostensibly is a review of epidemilogy methods. It is also a platform for Dr. Bérard to advance the pinions to which she has testified in birth defect lawsuits against anufacturers of serotonin reuptake inhibitors. These opinions are ot generally accepted; neither are they acceptable. The authors egin their paper using serotonin reuptake inhibitors as an examle of ...

1 Forrest AP, Stewart HJ, Everington D, et al. Randomised controlled trial of conservation therapy for breast cancer: 6-year analysis of the Scottish trial. Lancet 1996; 348: 708–13. 2 Fisher B, Bauer M, Margolese R, et al. Five-year results of a randomised clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer. N Engl J Me...

(Letter to the Editor) SIR, We read with great interest the report by Coleiro et al. [1] describing a pilot study on the tolerability and efficiency of fluoxetine for the treatment of Raynaud's phenomenon. This study confirmed previous case reports suggesting the usefulness of selective serotonin reuptake inhibitors (SSRIs) in the management of Raynaud's phenomenon [2, 3]. Here we describe for ...

BACKGROUND Fibromyalgia is a clinically well-defined chronic condition with a biopsychosocial aetiology. Fibromyalgia is characterized by chronic widespread musculoskeletal pain, sleep problems, cognitive dysfunction, and fatigue. Patients often report high disability levels and poor quality of life. Since there is no specific treatment that alters the pathogenesis of fibromyalgia, drug therapy...

Serotonin reuptake inhibitors (SRIs) are now considered the first-line treatment for depression, but they have not been well studied in bipolar disorder. Recently, some authors have recommended that patients at risk for antidepressant-induced mania be treated with SRIs rather than tricyclic antidepressants (TCAs). Clinical information about 11 patients who developed mania during treatment with ...