نتایج جستجو برای: serum metabolites
تعداد نتایج: 359947 فیلتر نتایج به سال:
Blood is a commonly used biofluid for biomarker discovery. Although blood lipid metabolites are considered to be potential biomarker candidates, their fundamental properties are not well characterized. We aimed to (1) investigate the matrix type (serum vs. plasma) that may be preferable for lipid biomarker exploration, (2) elucidate age- and gender-associated differences in lipid metabolite lev...
Quantitative NMR-based metabolite profiling is challenged by the deleterious effects of abundant proteins in the intact blood plasma/serum, which underscores the need for alternative approaches. Protein removal by ultrafiltration using low molecular weight cutoff filters thus represents an important step. However, protein precipitation, an alternative and simple approach for protein removal, la...
OBJECTIVE To identify metabolites showing changes in serum levels among Japanese male with diabetes. METHODS We performed metabolite profiling by coupling capillary electrophoresis with electrospray ionization time-of-flight mass spectrometry using fasting serum samples from Japanese male subjects with diabetes (n=17), impaired glucose tolerance (IGT; n=5) and normal glucose tolerance (NGT; n...
ANALYSIS OF THE BIOACTIVITY, METABOLISM, AND PHARMACOKINETICS OF ANTHOCYANINS IN HUMANS Colin Kay Advisors: University of Guelph, 2004 Professor B. J. Holub Professor G. Mazza Recent interest in the health-promoting properties of berry anthocyanins has been based on studies reporting their significant in vitro antioxidant activities. However, information regarding the bioavailability, metabolis...
PURPOSE To investigate the effect of lutein supplementation at doses of 2.5, 5.0, and 10 mg/d for 6 months on distribution of these carotenoids and their metabolites in the serum of elderly human subjects, with and without age-related macular degeneration. To determine whether supplementation with lutein can interact with the serum levels of other dietary carotenoids, retinol, and alpha-tocophe...
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