نتایج جستجو برای: sgc dense sets
تعداد نتایج: 275268 فیلتر نتایج به سال:
Cawley SM, Kolodziej S, Ichinose F, Brouckaert P, Buys ES, Bloch KD. sGC 1 mediates the negative inotropic effects of NO in cardiac myocytes independent of changes in calcium handling. Am J Physiol Heart Circ Physiol 301: H157–H163, 2011. First published May 2, 2011; doi:10.1152/ajpheart.01273.2010.—In the heart, nitric oxide (NO) modulates contractile function; however, the mechanisms responsi...
The nitric oxide receptor soluble guanylyl cyclase (sGC) exists in multimeric protein complexes, including heat shock protein (HSP) 90 and endothelial nitric oxide synthase. Inhibition of HSP90 by geldanamycin causes proteasomal degradation of sGC protein. In this study, we have investigated whether COOH terminus of heat shock protein 70-interacting protein (CHIP), a co-chaperone molecule that ...
Background Soluble guanylyl cyclase (sGC) is a ubiquitously expressed enzyme that synthesizes the second messenger cGMP. sGC has low basal activity which can be stimulated several hundred-fold by nitric oxide. Although, many NO activators and stimulators have been described only two chemically related sGC inhibitors exist: ODQ and NS-2028. The use of the above mentioned sGC inhibitors has helpe...
We build on Gruenhage, Natkaniec, and Piotrowski’s study of thin, very thin, and slim dense sets in products, and the related notions of (NC) and (GC) which they introduced. We find examples of separable spaces X such that X has a thin or slim dense set but no countable one. We characterize ordered spaces that satisfy (GC) and (NC), and we give an example of a separable space which satisfies (G...
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