Numerical descriptions of shock wave induced flows obtained with a two-dimensional Lagrangian finite difference code are compared in detail with experimental data obtained via the lateral relaxation method for polycrystalline magnesium oxide (MgO) to a pressure of 360 kbar. The equation of state used for MgO was assumed to be of the Mie-Griineisen form, and detailed comparison of experimental a...

Once plaques intrude into the lumen, the shear stress they are exposed to alters with hitherto unknown consequences for plaque composition. We investigated the relationship between shear stress and strain, a marker for plaque composition, in human coronary arteries. We imaged 31 plaques in coronary arteries with angiography and intravascular ultrasound. Computational fluid dynamics was used to ...

We use multi-arm star polymers as model soft colloids with tuneable interactions and explore their behaviour in the glassy state. In particular, we perform a systematic rheological study with a well-defined protocol and address aspects of ageing and shear melting of star glasses. Ageing proceeds in two distinct steps: a fast step of O(10(3) s) and a slow step of O(10(4) s). We focus on creep an...

Endothelial cells (ECs) sense shear stress and transduce blood flow information into functional responses that play important roles in vascular homeostasis and pathophysiology. A unique feature of shear-stress-sensing is the involvement of many different types of membrane-bound molecules, including receptors, ion channels and adhesion proteins, but the mechanisms remain unknown. Because cell me...

We present a reformulation of the ‘reactive rod model’ (RRM) Dutta and Graham (2018), constitutive model for describing behavior dilute wormlike micelle solutions. The RRM treats solutions as suspensions rigid Brownian rods undergoing reversible scission growth in flow. Evolution equations orientation stress contribution are coupled to kinetic reaction equation collective length, producing dyna...

In this paper, an elastic constitutive model based on the Eulerian corotational rate of the logarithmic strain tensor is proposed. Using this model, the large deformation of a closed cycle containing tension, shear, compression and inverse shear is analyzed. Since the deformation path includes a closed cycle and the material is considered as an isotropic elastic material, the normal and shear c...

Hemodynamic shear stress regulates endothelial cell biochemical processes that govern cytoskeletal contractility, focal adhesion dynamics, and extracellular matrix (ECM) assembly. Since shear stress causes rapid strain focusing at discrete locations in the cytoskeleton, we hypothesized that shear stress coordinately alters structural dynamics in the cytoskeleton, focal adhesion sites, and ECM o...

The focal location of atherosclerosis in the vascular tree is correlated with local variations in shear stress. We developed a method to induce defined variations in shear stress in a straight vessel segment of a mouse. To this end, a cylinder with a tapered lumen was placed around the carotid artery, inducing a high shear stress field. Concomitantly, regions of low shear stress and oscillatory...

In this paper, an elastic constitutive model based on the Eulerian corotational rate of the logarithmic strain tensor is proposed. Using this model, the large deformation of a closed cycle containing tension, shear, compression and inverse shear is analyzed. Since the deformation path includes a closed cycle and the material is considered as an isotropic elastic material, the normal and shear c...

The difference of sample preparation methods will directly lead to the structure sample, and mechanical response characteristics under external load be different. Based on conventional tests such as particle analysis, specific gravity, critical moisture content, consolidation test undisturbed loess from Xi’an, this paper focuses static triaxial consolidated drained shear undrained remolded loes...