Purpose The vertebrate rod photoreceptor undergoes daily growth and shedding to renew the rod outer segment (ROS), a modified cilium that contains the phototransduction machinery. It has been demonstrated that ROS shedding is regulated by the light-dark cycle; however, we do not yet have a satisfactory understanding of the molecular mechanisms that underlie this regulation. Given that phototran...

Genital herpes is most often transmitted while the patient is asymptomatic, presumably during episodes of viral shedding. To determine whether famciclovir is effective in reducing asymptomatic shedding, women with frequent, recurrent genital outbreaks were enrolled in a randomized, double-blind, double-dummy, placebo-controlled, parallel-group, 112-day trial of suppressive treatment with famcic...

Epidermal growth factor receptor (EGFR) activation by GPCRs regulates many important biological processes. ADAM metalloprotease activity has been implicated as a key step in transactivation, yet the regulatory mechanisms are not fully understood. Here, we investigate the regulation of transforming growth factor-alpha (TGF-alpha) shedding by reactive oxygen species (ROS) through the ATP-dependen...

,5dult tree squirrels (Seiurus carolinensis) entra,ined to a daily lighting cycle of I2L: 12D, display a biphasic rhythm of disc shedding. One peak occurs l-2 hr after light, onset. The second peak occurs during the middle of the dark period, a,bout three-quarters of a cycle out of phase with the morning peak. R’od disc shedding predominates in the morning, and cone shedding predominates during...

There are evidence that both a disintegrin and metalloproteinase 17 (ADAM17) and calpain are involved in platelet glycoprotein (GP)Ibalpha ectodomain cleavage. However, the relationship between the two enzymes in the shedding process remains unclear. Here we show that calcium ionophore A23187- and alpha-thrombin-induced GPIbalpha shedding is completely inhibited by the metalloproteinase inhibit...

when a distribution network consisting of distributed generations (dgs) is disconnected from upstream network, the system may be exposed to severe power imbalance. in order to prevent the damage of power plants, frequency relays operate and remove dgs from the network. in contrast to traditional methods, the main objective in new methods is to keep dg units in service in the islanded distributi...

this paper is a computational study of the behavior of aerodynamics  characteristics of an airfoil with blunt trailing edge and  studies the effects aerodynamic performance caused by modifications made to the trailing edge. blunt trailing edge airfoils are of interest in the engineering of large wind turbine blades because they allow for a strong structure with a high aerodynamic lift to struct...

immunoglobulin class switch recombination deficiencies (ig csr deficiencies) or hyper igm syndromes (higm) are a group of primary immunodeficiency diseases, characterized by defective cd40 signaling of b cells resulting into a csr and a somatic hypermutation. the affected patients are characterized with reduced serum levels of igg and iga, and normal or elevated level of igm, which lead to incr...

Cervical shedding of cytomegalovirus (CMV) is important in transmission of CMV to exposed sexual partners and neonates. We evaluated prevalence and correlates of CMV DNA shedding in cervical secretions from a large cohort of HIV-1-seropositive women. Using polymerase chain reaction (PCR) assays, CMV DNA was detected in 183 (59%) cervical swab samples from 311 women. Cervical shedding of CMV DNA...

Norovirus is a common cause of gastroenteritis in all ages. Typical infections cause viral shedding periods of days to weeks, but some individuals can shed for months or years. Most norovirus risk models do not include these long-shedding individuals, and may therefore underestimate risk. We reviewed the literature for norovirus-shedding duration data and stratified these data into two distribu...