Guillain Barre syndrome (GBS) is a rare but potentially fatal immune mediated disorder of peripheral nerves and nerve roots usually triggered by infections characterized ascending paralysis with or without sensory symptoms, hyporeflexia to areflexia. Usually preceded gastrointestinal respiratory infection. Post COVID-19 neurological manifestation include GBS, transverse myelitis etc., occur at ...

Oral urea has been used in the past to treat various diseases like gastric ulcers, liver metastases, sickle cell disease, heart failure, brain oedema, glaucoma, Meniere disease, etc. We have demonstrated for years, the efficacy of urea to treat euvolemic (SIADH) or hypervolemic hyponatremia. We briefly describe the indications of urea use in symptomatic and paucisymptomatic hyponatremic patient...

Abstract Introduction Diabetes mellitus (DM) is known to cause hyponatremia via multiple mechanisms and often a confounder in the diagnosis of syndrome inappropriate anti-diuretic hormone secretion (SIADH). However, not much about prevalence DM patients with SIADH or effect it has on outcomes hospitalizations for SIADH. Method: Data was extracted from US Nationwide Inpatient Sample (NIS) 2019. ...

Syndrome of inappropriate antidiuretic hormone (SIADH) secretion is an endocrinological disorder which occurs when there evidence continued (ADH) in the absence appropriate osmotic volume stimulus. Most commonly it caused by different types cancer or medications (eg. diuretics, antidepressants, antipsychotics...). Secondary adrenal insufficiency insufficient adrenocorticotropic (ACTH) and corti...

OBJECTIVE Tolvaptan, an oral antagonist of the vasopressin V(2) receptor, has been found to improve hyponatremia in patients with mixed etiologies. This study analyzed a subgroup of patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) to evaluate the efficacy and safety of tolvaptan in this group. DESIGN AND PATIENTS Hyponatremic patients in the SALT-1 and SALT-2...

AIMS Hyponatraemia (HN) is the most common electrolyte balance disorder in clinical practice. Since the 1970s, demeclocycline has been used in some countries to treat chronic HN secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH). The precise mechanism of action of demeclocycline is unclear, but has been linked to the induction of nephrogenic diabetes insipidus. Furthe...

Euvolemic hyponatremia in the setting of lung cancer is most commonly due to the syndrome of inappropriate anti-diuretic hormone secretion (SIADH). However, a subset of patients with small cell carcinoma and hyponatremia also have elevated levels of atrial natriuretic peptide (ANP), which is produced by some small cell tumors. We report the case of a 64-year-old man with a limited-stage small c...

SIR, Kaushik and Binymin raise the interesting suggestion of a link between rheumatoid arthritis and the syndrome of inappropriate antidiuretic hormone (SIADH) [1]. The serum and urine osmolality results and urine sodium excretion do not, however, confirm the diagnosis of SIADH. Previous serum urea and creatinine concentrations and clinical features such as oedema, blood pressure and pulse are ...