CONTEXT Premarital haemoglobin screening is an important strategy for the control of Sickle Cell Disease. AIMS To determine the prevalence and pattern of sickle cell disease among premarital couples and to assess their attitude to the risk of sickle cell anaemia in their offspring. SETTINGS AND DESIGN A cross sectional descriptive study using interviewer administered questionnaire and haemo...

INTRODUCTION Avulsion of permanent teeth in children resulting from trauma is an acute emergency presentation. When not adequately managed, it may result in functional and aesthetic disturbances, with implications for more complicated and prolonged treatment which require planning and biocompatibility in terms of forces used in moving the teeth orthodontically. Literature is scarce on a reporte...

Studies have questioned whether renal dysfunction in sickle cell disease is linked to hemolysis-associated vasculopathy. We have investigated renal function and markers of hemolysis in a cohort of 424 adult African-British patients with sickle cell disease. While significant associations were found in HbSS and HbSβ(0) (sickle cell anemia) patients with and without controlling for covariates bet...

patients with sickle cell anaemia was shown promptly to decrease the incorporation of radioactive iron into red cells and cause reticulocytopenia and rapid worsening of the anaemia. These events reversed rapidly when administration of oxygen was stopped.2 The haematological events in our patient are identical to those observed in that study, which also showed that patients with pernicious anaem...

Plasma fibrinogen concentration and whole-blood viscosity, the latter measured at two shear rates (23 and 230 sec-1), were estimated during eight episodes of sickle-cell crisis and compared with values in 26 sickle-cell anaemia patients who were not in crisis. Painful crisis was associated with a significant increase in both plasma fibrinogen and whole-blood viscosity. Increased fibrinogen-eryt...

Sickle cell disease (SCD) is one of the most common inherited disorders of haemoglobin in Africa and it is expected that sickle cell trait varies in frequency in different areas in Sudan. An extensive literature search was carried out accessing the US National Library of Medicine, the WHO Eastern Mediterranean Region resources, the Catalogue for Transmission Genetics in Arabs and papers and doc...