In a 4-isopropyl-1-oxa-3-oxonia-2-borata-naphthalene the isopropyl group exhibits the same conformational phenomena as the Me2N group in 8-dimethylamino-naphth-1-yl-silanes and related phosphorus compounds. Since the details can be fully rationalized on the basis of the steric situation and electronic factors are excluded, the common features cannot serve to infer dative interaction from nitrog...

The combined use of silanes (Et3SiH or PMHS) and I2 as novel N-glycosidation reagents for the synthesis of bioactive oxathiolane nucleosides 3TC and FTC is reported. Both systems (working as anhydrous HI sources) were devised to act as substrate activators and N-glycosidation promoters. Excellent results in terms of chemical efficiency and stereoselectivity of the reactions were obtained; surpr...

Cyclic alkenylsiloxanes were synthesized by semihydrogenation of alkynylsilanes-a reaction previously plagued by poor stereoselectivity. The silanes, which can be synthesized on multigram scale, undergo Hiyama-Denmark coupling to give (Z)-alkenyl polyene motifs found in bioactive natural products. The ring size of the silane is crucial: five-membered cyclic siloxanes also couple under fluoride-...

The B(C6F5)3-catalyzed silylative reduction of conjugated nitriles has been developed to afford synthetically valuable β-silyl amines. The reaction is chemoselective and proceeds under mild conditions. Mechanistic elucidation indicates that it proceeds by rapid double hydrosilylation of the conjugated nitrile to an enamine intermediate which is subsequently reduced to the β-silyl amine, thus fo...

Silane coupling agent generally use as improve the properties of white filler use in rubber compound for better dispersion. Also silane coupling agent reacts with organic filler & polymer chain as crosslink. Here in this research study the crosslink density & swelling phenomena of silane participate in vulcanization process with Nitrile rubber compound. Also show the comparisons of carbon fille...

A Rh-catalyzed regiodivergent hydrosilylation of acyl aminocyclopropanes has been developed. Acyl aminocyclopropanes were reacted with hydrosilanes in the presence of Rh catalysts to afford ring-opened hydrosilylated adducts through carbon–carbon (C–C) bond cleavage of the cyclopropane ring. The regioselectivity of the addition of silanes (linear or branched) can be switched by changing the mon...

Exposures to two commercial nanofilm spray products (NFPs), a floor sealant (NFP 1) and a coating product for tiles (NFP 2), were investigated for airway irritation, airway inflammation, and lung damage in a mouse inhalation model. The particle exposure was characterized by particle number, particle size distribution, and gravimetric analysis. BALB/cJ mice were exposed for 60 min to the aerosol...

The immobilization of antibodies on various surfaces has been the subject of advanced research in various immunoassay-based diagnostic devices. The physical and chemical stabilities of the immobilized antibodies on a solid surface still cause many problems because upon immobilizing antibody molecules, the antigen-binding ability usually decreases. The silanization of surfaces with organosilanes...

The past few years have witnessed a profusion of highly efficient, catalytic, enantioand diastereoselective alkylations of carbonyl compounds.1 At the present time, the alkylation of the imino functional group presents a timely challenge in asymmetric catalysis, and recent work has focused on enol silanes, silyl ketene acetals, and TMSCN as carbon-based nucleophiles.2 We recently reported a mea...

Experimental control over cellular polarity in a neuronal network is a promising tool to study synapse formation and network behavior. We aimed to exploit a mechanism described by Stenger et al. [J. Neurosci. Methods 82 (1998) 167] to manipulate the direction of axonal versus dendritic outgrowth on a micropattern. The group had used laser ablation to create patterns of aminated silanes for cell...