BACKGROUND Several quantification algorithms for measuring left ventricular (LV) size and function are used in clinical and research settings. The aims of this study were to investigate the effects of measurement algorithm and beat averaging on the reproducibility of measurements of the left ventricle and to assess the magnitude of agreement among the algorithms in children with dilated cardiom...

WW domains are small domains present in many human proteins with a wide array of functions and acting through the recognition of proline-rich sequences. The WW domain belonging to polyglutamine tract-binding protein 1 (PQBP1) is of particular interest due to its direct involvement in several X chromosome-linked intellectual disabilities, including Golabi-Ito-Hall (GIH) syndrome, where a single ...

The direction of an association at the population-level may be reversed within the subgroups comprising that population-a striking observation called Simpson's paradox. When facing this pattern, psychologists often view it as anomalous. Here, we argue that Simpson's paradox is more common than conventionally thought, and typically results in incorrect interpretations-potentially with harmful co...

The aim of this study was to identify in rat hepatocytes cellular polypeptides that bind protein kinase C (PKC) and may influence its activity and its compartmentation. At least seven proteins, with apparent M(r) values between 12,000 and 36,000, that behave like Receptors for Activated C-Kinase (RACKs) were found in the Triton-X-100-insoluble fraction of these cells; i.e. PKC bound to these po...

Kaur et al 1 have produced a timely systematic review on the role of adjuvant radiotherapy for atypical meningioma (AM) and malignant meningioma. Their review highlights the paucity of good quality prospective studies and the urgent need for prospective clinical trials for AM. Kaur et al 1 identify extent of resection (EOR) as an important prognostic factor but fail to comment on how this was d...

James Young Simpson was one of the first obstetricians to administer anesthesia during childbirth in nineteenth century Scotland. Before his work in the 1800s, physicians had few ways to reduce the pain of childbirth. Simpson experimented with the use of ether and chloroform, both gaseous chemicals, to temporarily relieve pain. He found that those chemicals both successfully inhibited the pain ...

The Deligne-Simpson problem asks to find a condition on conjugacy classes C1, . . . , Ck ⊂ Matn(C) such that there are matrices Yi ∈ Ci with (1) ∑k i=1 Yi = 0, (2) and there are no proper subspaces in C stable under all Yi. Crawley-Boevey reduced this problem to checking if there is an irreducible representation in Rep(Π(Q), v) for suitable Q, λ, v produced from C1, . . . , Ck. Recall, Section ...

Only three of the essays are taken from Aequanimitas, which is still readily available. The value of the collection is greatly enhanced by the commentaries of the fourteen distinguished American medical specialists and librarians, which puts each essay critically in perspective. In the sum of its parts, it is a book which may be read and enjoyed by those who are interested in medical education ...

We introduce a new concept “GA-"-convex function” and establish some inteNote 1: Red parts indicate major changes. Please check them carefully. gral inequalities of Simpson type for GA-"-convex functions.