chemical structure. The pharmacological studies on SIN-10 by Takenaka et al. (2) showed a sustained hypotensive effect in rabbits. The similar effect was also confirmed in the dog, cat and rat by Kikuchi et al. (3). In order to provide a biochemical basis for the pharmacological and toxicological mechanisms, the metabolic aspects of SIN-10 have been studied in rats and mice. The present paper d...

Five species of sigmodontine rodents have been identified in Argentina as the putative reservoirs of six circulating hantavirus genotypes. Two species of Oligoryzomys are associated with the genotypes causing hantavirus pulmonary syndrome, Oligoryzomys flavescens for Lechiguanas and O. longicaudatus for Andes and Oran genotypes. Reports of human cases of hantavirus pulmonary syndrome prompted r...

We hypothesized that the ongoing naturalization of frost/shade tolerant Asian bamboos in North America could cause environmental consequences involving introduced bamboos, native rodents and ultimately humans. More specifically, we asked whether the eventual masting by an abundant leptomorphic ("running") bamboo within Pacific Northwest coniferous forests could produce a temporary surfeit of fo...

1. Hopefully, every group accomplished at least some work this week on project 2. 2. (a) You can do this problem in two ways. The first way is attaching frames to each link and determining the Denavit–Hartenberg parameters, as illustrated in Figure 1. Referring to the figure, the link parameters are: i α i−1 a i−1 d i θ i 1 0 0 0 θ 1 2 0 l 1 0 θ 2 3 0 l 2 0 θ 3 Using equation 3.6 or your Mathem...

Since the first observation in 1964, CP violation remains one of the most elusive aspects of the standard model. The CDF collaboration has reported the first evidence of CP violation in the B system using the world’s largest sample of B → J/ψK S decays. The direct measurement of sin(2β)=0.79 −0.44 (combined statistical and systematic error) agrees with the standard model predictions. New data c...

Sinefungin (SIN), a natural S-adenosyl-L-methionine analog produced by Streptomyces griseolus, is a potent inhibitor of methyltransferases. We evaluated the effect of SIN on replication of vesicular stomatitis virus (VSV), a prototype of the nonsegmented negative-strand RNA viruses. The 241-kDa large polymerase (L) protein of VSV methylates viral mRNA cap structures at the guanine-N-7 (G-N-7) a...

Semliki Forest virus (SFV) and Sindbis virus (SIN) are enveloped alphaviruses that enter cells via low-pH-triggered fusion in the endocytic pathway and exit by budding from the plasma membrane. Previous studies with cholesterol-depleted insect cells have shown that SFV requires cholesterol in the cell membrane for both virus fusion and efficient exit of progeny virus. An SFV mutant, srf-3, show...

This paper describes SiN, a novel case-based planning algorithm that combines conversational case retrieval with generative planning. SiN is provably correct, and can generate plans given an incomplete domain theory by using cases to extend that domain theory. SiN can also reason with imperfect world-state information by incorporing preferences into the cases. Our empirical validation shows how...

Our studies have concentrated on elucidating the role of the signaling protein Sin in T-lymphocyte function. We have previously shown that Sin overexpression inhibits T-lymphocyte development and activation. Here we show that Sin-deficient mice exhibit exaggerated immune responses characterized by enhanced cytokine secretion and T-cell-dependent antibody production. Excessive T-cell responses i...