Throughout life, people experience all kinds of relationships. While healthy relationships have the potential to improve feelings of self-worth, enjoyment, and personal growth, unhealthy relationships may leave people feeling disrespected, controlled, and in some circumstances, unsafe. Keep in mind that in all kinds of partnerships, there is likely to be some disagreement, need for compromise, ...

Throughout life, people experience all kinds of relationships. While healthy relationships have the potential to improve feelings of self-worth, enjoyment, and personal growth, unhealthy relationships may leave people feeling disrespected, controlled, and in some circumstances, unsafe. Keep in mind that in all kinds of partnerships, there is likely to be some disagreement, need for compromise, ...

We report the identification of deoxynivalenol-3-sulfate and deoxynivalenol-15-sulfate as two novel metabolites of the trichothecene mycotoxin deoxynivalenol in wheat. Wheat ears which were either artificially infected with Fusarium graminearum or directly treated with the major Fusarium toxin deoxynivalenol (DON) were sampled 96 h after treatment. Reference standards, which have been chemicall...

Deoxynivalenol (DON), produced by the plant pathogens Fusarium graminearum and Fusarium culmorum, is one of the most common mycotoxins, contaminating cereal and cereal-derived products. Although worldwide contamination of food and feed poses health threats to humans and animals, pigs are particularly susceptible to this mycotoxin. DON derivatives, such as deepoxy-deoxynivalenol (DOM-1), are pro...

To evaluate the fate of deoxynivalenol (DON) in broilers, DON was administered either intravenously or orally to broilers at a dose of 1 mg/kg BW. Concentrations of DON in plasma were measurable up to 4 hr and 2 hr after intravenous and oral administration, respectively. Following intravenous administration, the values for the elimination half-life, the volume of distribution and the clearance ...

Two experiments were conducted to evaluate potential detoxifying agents on growth of nursery pigs fed deoxynivalenol (DON)-contaminated diets. Naturally DON-contaminated wheat (6 mg/kg) was used to achieve desired DON levels. In a 21-d study, 238 pigs (13.4 ± 1.8 kg BW) were used in a completely randomized design with a 2 × 2 + 1 factorial arrangement. Diets were: 1) Positive control (PC; < 0.5...

Throughout life, people experience all kinds of relationships. While healthy relationships have the potential to improve feelings of self-worth, enjoyment, and personal growth, unhealthy relationships may leave people feeling disrespected, controlled, and in some circumstances, unsafe. Keep in mind that in all kinds of partnerships, there is likely to be some disagreement, need for compromise, ...

Throughout life, people experience all kinds of relationships. While healthy relationships have the potential to improve feelings of self-worth, enjoyment, and personal growth, unhealthy relationships may leave people feeling disrespected, controlled, and in some circumstances, unsafe. Keep in mind that in all kinds of partnerships, there is likely to be some disagreement, need for compromise, ...

Incubation of embryonic chick chondrocytes with 6-diazo-5-oxo-L-norleucine (DON), a glutamine analogue, led to a dose-dependent inhibition of [35S]sulfate incorporation into proteoglycan. In the absence of exogenous L-glutamine, a maximal inhibition of 50-60% was achieved with DON concentrations greater than or equal to 1 microgram/ml (6 microM); the ED50 was approximately 0.2 microM. This inhi...

Non-volatile sesquiterpenoids, a trichothecene family of phytotoxins such as deoxynivalenol (DON) and T-2 toxin, contain numerous molecular species and are synthesized by phytopathogenic Fusarium species. Although trichothecene chemotypes might play a role in the virulence of individual Fusarium strains, the phytotoxic action of individual trichothecenes has not been systematically studied. To ...