The present study was conducted to test the effect of Origanum Majoranum Extract (OME) of leaves on alterations induced in a model of type 2 diabetic rats. Adult male Wistar rats were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetic rats. Diabetic rats were given aqueous extract of OME in a dose of 20 mg/kg orally ...

SUMMARY Cisplatin is a widely used anticancer agents that is effective against ovarian and other tumors. This drug is recognized as nephrotoxic in human and experimental animals. The effect of cisplatin-induced kidney injury was predominantly investigated in male animals. This study was designed to assess effects of cisplatin on male and female rat kidneys. We also investigated the effect of g...

Duplex kidney (DK) is the most common congenital abnormality of the urinary tract, with an incidence of around 0.82%1,2. Basis of duplex kidney formation by embryology is explained as development of two ureteral buds separately from a single mesonephric duct gives rise to a duplex kidney with complete ureteral duplication. On the other hand, bifurcation of a single ureteral bud proximal to the ...

Objective: Physical activity and herbal medicine can inhabit apoptosis with two different mechanisms. The aim of this study was to assess the combined effect of regular aerobic exercise with garlic extract on heart apoptosis regulatory factors in aged rats with chronic kidney disease. Materials and Methods: In this experimental research, 42 aged male Wistar rats (48-52 weeks) were selected and...

background: this study examined the effect of grape seed proanthocyanidin extract (gspe) on lipid peroxidation content and activity of tissue antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase in diabetic rats. methods: thirty male rats were divided into three groups of 10 rats each: control, diabetic and diabetic groups that received 500 mg/kg gspe for 6 w...

patients and methods from march 1976 to december 2013, the number of patients that underwent living renal transplantation sharing at least one hla haplotype with their donors was 2,485. we divided these patients into two groups: (1) 2,075 kidney transplant recipients (1,554 or 74.9% male and 521 or 25.1% female) for whom the donors were living related, (2) 410 kidney transplant recipients (297 ...

Background: This study examined the effect of grape seed proanthocyanidin extract (GSPE) on lipid peroxidation content and activity of tissue antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase in diabetic rats. Methods: Thirty male rats were divided into three groups of 10 rats each: control, diabetic and diabetic groups that received 500 mg/kg GSPE for 6 w...

objective: methotrexate is an antimetabolite drug commonly prescribed for the various cancers and autoimmune diseases. despite its considerable therapeutic effects, nephrotoxicity is the most important side-effect of treatment with methotrexate. aquaporin1 is a water channel proteins which are present in mammalian kidney. raspberry fruit with antioxidant properties is able to protect biological...