BACKGROUND AND PURPOSE Retinoblastoma may exhibit variable hyperintensities on DWI, resulting in different values in the ADC maps, depending on their histology and cellularity. However, EP-based DWI has susceptibility artifacts and image distortions, which make DWI of the orbit a challenging technique. The aim of this study was to investigate the feasibility of single-shot turbo spin-echo (HAST...

BACKGROUND The aim of this study was to investigate the role of diffusion-weighted MR imaging (DWI) in the diagnosis of gastric tumors by means of measuring the apparent diffusion coefficient (ADC) values of these lesions, and making a comparison with the endoscopic biopsy results. SUBJECTS AND METHODS Seventy patients having gastric tumor constituted the case group. For the control group 30 ...

Chemoimmunotherapywith antibody–drug conjugates (ADC) is emerging as a promising therapy for solid tumors, whereas radioimmunotherapy (RAIT) of solid tumors has been relatively ineffective because of their resistance to radiation. We developed antibody–SN-38 conjugates that have significant antitumor activity in xenograft models at nontoxic doses. The goal of this study was to determine if an A...

Introduction: Most common glioma tumors are tumors of the central nervous system (CNS) which are the cause of about 40 to 50 percent of brain tumors. This type of cancer includes 2 to 3 percent of cancers in the world. Conventional MRI is powerless in the detection and differentiation of benign and malignant tumors. In this case, diffusion weighted imaging (DWI) can create cont...

A novel high-order single-loop incremental sigmadelta ADC for multi-channel applications is proposed. Highorder continuous-time architectures are explored using a 3rd order single-bit modulator as a test-case. The performance of the proposed architecture, taking into account critical nonidealities, is analyzed and its advantages and issues are discussed. Behavioral simulations show a key advant...

This paper proposes the design of a 6-bit single-ended SAR ADC with a variable sampling rate at a maximum achievable speed of 50 MS/s. The SAR ADC utilizes the split capacitor array DAC with a non-conventional split-capacitor value. The influence of switches in the capacitive DAC on the ADC’s non-linearity is analysed. According to the fulfilled analysis the recommendations for switches and cap...

This paper describes a 12-bit 100kS/s successive approximation register analog-todigital converter (SAR ADC) for biomedical system. Both top-plate sampling technique and VCM-based switching technique are applied to the capacitor digital-to-analog converter (CDAC) to implement a 12-bit SAR ADC with 10-b capacitor array DAC. To enhance the linearity of proposed ADC, thermometer decoder is used in...

OBJECTIVE To compare the apparent diffusion coefficient (ADC) values of upper abdominal organs with 2 different 3.0 tesla MR systems and to investigate the usefulness of normalization using the spleen. MATERIALS AND METHODS Forty-one patients were enrolled in this prospective study, of which, 35 patients (M:F, 27:8; mean age ± standard deviation, 62.3 ± 12.3 years) were finally analyzed. In a...

Purpose: Alpha-1 antitrypsin deficiency (AATD) affects approximately 1 in 1500 people of European1 descent and is characterized by predominate basal lung emphysema which manifests early in life. This study builds upon previous studies in AATD which examine apparent diffusion coefficients (ADC) using a single diffusion weight. We extend the traditional single diffusion weighted ADC approach into...