Cancer stem cells (CSCs) are suggested as the most dominant causes of recurrence due to their permanent self-renewal and resistance to common cancer treatment in glioblastoma multiform (GBM) which is recognized as the most malignant of brain tumor. It has been indicated that Retinoblastoma-binding protein 5 (RBBP5), a main part of Mixed lineage leukemia protein-1 (MLL1), plays a significant rol...

Biomphalaria glabrata is one of the snail intermediate hosts Schistosoma mansoni , causative agent intestinal schistosomiasis disease. Numerous molecular studies using comparative approaches between susceptible and resistant snails to S. infection have helped identify numerous key candidates supporting such susceptible/resistant status. The functional approach RNA interference (RNAi) remains cr...

Nucleic acid-based therapy with plasmid DNA (pDNA) and small interfering RNA (siRNA) have received recent attention for their ability to modulate the cellular expression of genes proteins. Polyethylene glycol-modified (PEGylated) cationic nanoparticles been used as non-viral vectors in vivo delivery these nucleic acids. We reported that PEGylated liposomes (PCL) including pDNA or siRNA induce a...

RNA(i) interference is a gene silencing mechanism triggered by double-stranded (ds)RNA, which promises to contribute species-specific insect pest control strategies. The first step toward the application of RNAi as an insecticide enable efficient upon dsRNA oral delivery. desert locust, Schistocerca gregaria devastating agricultural pest. While this species responsive delivered intra-hemocoelic...

Tailored end-group modifications and the formulation of cell-penetrating urea-based foldamers enable efficient siRNA delivery into cells.