To understand infection mechanisms, the stability of the solution for continuous epidemic models is often discussed. However, Acedo et al. [1] recently proposed a formal solution for a continuous SIRS model. We apply analytical approach by [1] to a discretized SIRS model. This analytical approach can not be applied to discretized model using traditional numerical schemes. Sekiguchi and Ishiwata...

Systemic inflammatory response syndrome (SIRS) is a common complication after cardiovascular surgery that in severe cases can lead to multiple organ dysfunction syndrome and even death. We therefore set out to identify reliable early biomarkers for SIRS in a prospective small patient study for timely intervention. 21 Patients scheduled for planned cardiovascular surgery were recruited in the st...

STUDY OBJECTIVES Most natural history studies of severe sepsis are limited to ICU populations. We describe the onset and timing of severe sepsis during the hospital course for patients hospitalized with community-acquired pneumonia (CAP). We also determine the ability of the systemic inflammatory response syndrome (SIRS) and other proposed risk stratification scores measured at emergency depart...

INTRODUCTION Because the use of procalcitonin (PCT) as a marker of bacterial infection has been advocated, this study was carried out to determine the usefulness of plasma PCT in the early diagnosis and differentiation of patients with non-infectious systemic inflammatory response syndrome (SIRS) from those with sepsis, and the relationship between plasma PCT level and severity of organ failure...

Abstract Background Many early warning scores (EWSs) have been validated to prognosticate adverse outcomes secondary sepsis in the Emergency Department (ED). These EWSs include Systemic Inflammatory Response Syndrome criteria (SIRS), quick Sequential Organ Failure Assessment (qSOFA) and National Early Warning Score (NEWS). However, Rapid Medicine (REMS) has never for this purpose. We aimed asse...

INTRODUCTION EPIDEMIOLOGY The Civilian Experience The Military Experience Traumatic Injury Trauma-Related Sepsis and Septic Shock Cellular and Subcellular Mechanisms Leading to SIRS/MODS Components and Products From Microorganisms Giving Rise to SIRS/MODS Cellular Components Contributing to SIRS/MODS Endogenous Mediators ORGAN-SPECIFIC RESPONSES Cardiovascular Response Pulmonary Response Renal ...

In patients with systemic inflammatory response syndrome (SIRS), tolerance of peripheral blood mononuclear cells to a second challenge with lipopolysaccharide (LPS) has been described. Thoracic duct lymph transports LPS and represents the extravascular, interstitial fluid compartment of the body. The aim of this study was to determine the capacity of lymph to influence LPS-induced cytokine prod...

BACKGROUND Differential diagnosis of systemic inflammatory response syndrome (SIRS) with or without infectious cause is critically important in terms of initiating antimicrobial agents in case of infectious etiology such as ventilator-associated pneumonia (VAP). The aim of this study was to determine the diagnostic and prognostic roles of C-reactive protein (CRP) and tumor necrosis factor-alpha...

INTRODUCTION Cardiopulmonary bypass (CPB) has often been compared to the pathophysiologic changes occurring in sepsis or systemic inflammatory response syndrome (SIRS). The definitions for SIRS is classically considered to be related to sepsis, shock, and multiple organ dysfunction syndrome (MODS).1 The idea behind defining SIRS was to define a clinical response to a nonspecific insult of eithe...