PURPOSE Nanosuspension in drug delivery is known to improve solubility, dissolution and eventually bioavailability of the drugs. The purpose of the study was to compare particle size of nanosuspensions prepared by the first generation approach and H96 approach and to evaluate the effectiveness of H96 approach. METHODS The nanosuspension of aprepitant was prepared by HPH and H96 approach. The ...

1. Salazar, Jaime; Müller, Rainer H.; Möschwitzer, Jan P., (2009), “Systematic investigationto establish optimal process parameters for a novel particle size reduction method”, AnnualMeeting of the German Pharmaceutical Society (DPhG), Jena/Germany, September 28 –October 1, 2009. Poster presentation, abstract C48, booklet page 45. 2. Salazar, Jaime; Ghanem, Antoine; Müller, Rainer H...

in this study, synthesis of copper nanoparticles and effect of the reaction conditions on the particle size were investigated. the copper nanoparticles were synthesized and stabilized in a narrow temperature range in the presence of polyvinylpyrrolidone under nitrogen atmosphere. reaction temperature and concentration ratio of the reducing agent to the precursor (r/p) as two main conditions i...

introduction: in the present study, potential differences between the effects of l-carnitine (lc) and acetyl-lcarnitine (alc) on ischemia/reperfusion (i/r)-induced myocardial infarction size were investigated. methods: male wistar rats were randomly divided into five groups and then anesthetized by sodium pentobarbital. hearts of the animals were removed and quickly mounted on a langendorff app...

In this research, a new exhaust manifold and its cooling jackets is first designed for the integrated exhaust manifold into cylinder head (IEMCH) for a turbocharged engine. Then, the gas exchange and flow analysis is carried out numerically to evaluate the proper conditions for the exhaust gas and the coolant stream respectively. Finally, the entire engine parts are thermally analyzed to assure...