Cancer chemotherapy can fail in many ways. One of the most significant is the development of multiple drug resistance (MDR), which constitutes a serious clinical problem. The development of MDR relates to the expression of a major membrane pump, P-glycoprotein (P-gp). Thus, currently one of the goals of experimental and clinical oncology is to decrease its activity. So far, many different P-gp ...

This study presents numerical work to investigate the Falkner–Skan flow of a bio-convective Casson fluid over wedge using an Evolutionary Padé Approximation (EPA) scheme. The governing partial differential equations and boundary conditions model are transformed system ordinary involving ten dimensionless parameters by similarity transformations. In proposed EPA framework, equivalent constrained...

The effects of roughness parameters, including height, diameter, and spacing the cylindrical elements, on turbulent transition are investigated in a three-dimensional boundary layer using direct numerical simulation. There two types process, classified as gradual forced. former is caused by linear development crossflow vortices their secondary instability, while latter an immediate breakdown to...

Laminar-to-turbulent transition in a swept flat-plate boundary layer is caused by the breakdown of crossflow vortex via high-frequency secondary instability and promoted wall-surface roughness freestream turbulence (FST). Although FST characterized its intensity wavelength, it not clear how wavelength affects turbulent transitions interacts with roughness-induced transition. The depends on wind...

The aim of this work is the study of the two dimensional laminar compressible boundary layer ̄ow, with an adverse pressure gradient in the presence of heat and mass transfer. The partial di€erential equations and their boundary conditions, describing the problem under consideration, are transformed using the compressible Falkner±Skan transformation and the numerical solution of the problem is o...

A theoretical flow solution is presented for predicting the pressure distribution along the vocal fold walls arising from asymmetric flow that forms during the closing phases of speech. The resultant wall jet was analyzed using boundary layer methods in a non-inertial reference frame attached to the moving wall. A solution for the near-wall velocity profiles on the flow wall was developed based...