BACKGROUND Neuronal intranuclear inclusion disease (NIID) is a progressive neurodegenerative disease characterized by eosinophilic hyaline intranuclear inclusions in neuronal and somatic cells. Because of the variety of clinical manifestations, antemortem diagnosis of NIID is difficult. METHODS Seven skin biopsy samples from patients with familial NIID were evaluated histochemically, and the ...

We describe a 31-year-old man, a known case of hepatitis C infection for 11 years, who presented with a chronic non-healing large deep ulcer on the dorsum of the right foot for five months. Fusarium solani infection was confirmed by skin biopsy and culture. The biopsy specimen showed an unusually extensive dermal invasion with fungal hyphae. The patient's response to oral itraconazole 100 mg/da...

We present a case of a woman, 79 years old, followed by Psychiatry for depressive episodes after breast cancer removal. She was operated on for ductal breast carcinoma in 1983. Afterward she was submitted to adjuvant radiotherapy. She came to our attention for a chronic skin ulcer that developed into the radio-treated area about 4 years ago. We performed a skin biopsy and programed adipose tiss...

A 46-year-old woman presented with a slowly enlarging skin lesion on the back, jugular lymphadenopathy for 1 month, but no fever. She was infected with the human immunodeficiency virus (HIV); CD4+ T lymphocyte count was 22 cells/ mm. She had always lived in Hubei province (central China) and denied a history of traveling to southern China. The skin lesion was 3 +3 cm flesh-colored, well-demarca...

Skin biopsy has become a widely used tool to investigate small calibre sensory nerves including somatic unmyelinated intraepidermal nerve fibres (IENF), dermal myelinated nerve fibres, and autonomic nerve fibres in peripheral neuropathies and other conditions. Different techniques for tissue processing and nerve fibre evaluation have been used. In March 2004, a Task Force was set up under the a...

Introduction Skin tissue contamination within transcutaneous visceral organ biopsies is seldom found. We encountered a rare case of extramammary Paget's disease incidentally diagnosed by prostate biopsy during active surveillance for cancer. Case presentation A 71-year-old Japanese patient was with cancer, and selected. After 1 year, performed transperitoneal approach, 16 cores were taken. One ...

The present study was designed to assess the frequency and stage of skin neurofibroma in the samples of patients with age, gender and biopsy locations. Data obtained from annual record files of four different pathology centers with considering factors of diagnosis, age, and gender and biopsy location, examined for statistical difference. Each diagnosis has been coded by ICD method. Statistical ...

The present study was designed to assess the frequency and stage of skin neurofibroma in the samples of patients with age, gender and biopsy locations. Data obtained from annual record files of four different pathology centers with considering factors of diagnosis, age, and gender and biopsy location, examined for statistical difference. Each diagnosis has been coded by ICD method. Statistical ...