macular or maculopapular skin reactions are frequent events in skin allergies as well as in viral infections. clinically, the differentiation may be difficult in the absence of a clear relationship with drug intake or in the failure to detect measles virus-specific antibodies. studies on drug-specific t cell lines and t cell clones isolated from skin-allergy patients have suggested that these c...

Rifampin is commonly used as a first-line anti-tuberculosis drug, but it can induce a serum sickness-like reaction or anaphylaxis. However, it is possible for 1 drug antigen to induce 2 or more simultaneous immunologic reactions. Here, we report a case of a serum-sickness-like reaction and anaphylaxis induced concurrently by rifampin. A 25-year-old male presented with high fever and a maculopap...

background: listeria monocytogenes is one of the most important food-borne bacteria causing septicemia, meningitis and encephalitis in humans. the objective of this study was to evaluate the occurrence and antibiotic resistance of the bacterium in retail minced beef in ahvaz, south-west of iran. methods: in this survey, 150 samples of minced beef were randomly obtained from retail butcheries in...

magnetic resonance imaging (mri) contrast agents most commonly agents used in diagnosing different diseases. several agents have been ever introduced with different peculiar characteristics. they vary in potency, adverse reaction and other specification, so it is important to select the proper agent in different situations. we conducted a systematic literature search in medline/pubmed, web of s...

Drug hypersensitivity reactions are unpredictable adverse drug reactions. ey manifest either within 1–6 h following drug intake (immediate reactions) with mild to life-threatening symptoms of anaphylaxis, or several hours to days later (delayed reactions), primarily as exanthematous eruptions. It is not always possible to detect involvement of the immune system (allergy). Waiving diagnostic tes...

Background Adverse reactions to drugs, Fixed Erythema (FE), correspond to 16-21% of all skin eruptions. This disease results in the development of one or more erythematous annular or oval, plaques as a result of systemic exposure to a drug. On reexposure relapse occurs in the same place, although new lesions may arise simultaneously in other areas. Any drug can cause FE. The physiopathology inv...

materials and methods liposomes were prepared by thin film method using soya lecithin and cholesterol. physicochemical characteristics of the liposomes such as, particle size, drug encapsulation efficiency were determined. also, drug release and in vitro skin permeability through rat skin were evaluated using franz diffusion cells. results the results showed that the maximum drug encapsulation ...

BACKGROUND Few studies have been performed in children with suspected betalactam allergy. We aimed to assess the role of the drug provocation test (DPT) with betalactams in a paediatric setting and to study the association between allergy to betalactam antibiotics and other allergic diseases. METHODS We included all the patients under 15 years old who were consecutively referred to the Immuno...

Background Severe exfoliative diseases of the skin (Erythema multiforme, Stevens–Johnson syndrome SJS, toxic epidermal necrolysis -TEN) are a result of an immunological reaction to foreign antigens, most frequently caused by drug consumption. It is characterized by extensive damage to the skin and mucous membranes due to detachment at the dermoepidermal junction, very similar to post-combustion...

Meglitinides (repaglinide and nateglinide) are insulin secretagogues used to treat diabetes mellitus. We present a case of hypersensitivity reaction to repaglinide in a 61-year-old man who developed a maculopapular rash 5 days after treatment. Skin prick tests including repaglinide (0.5 g/mL) and patch tests (0.05% in pet and saline) were performed, and the results were negative. A blind oral c...