Metastasis to the bone represents a frequent complication of visceral cancers, most commonly in patients with advanced breast, prostate, and lung cancer. More than 50% of patients with advanced breast or prostate cancer have identifiable bone metastasis, and 30% to 40% of patients with non-small-cell lung cancer ultimately develop metastases to bone. Most tumors preferentially metastasize to th...

Unilateral isolated Hypoglossal nerve palsy may result due to neoplasia, trauma, infections, autoimmune or vascular causes. We report a 52 year old male who presented with right hypoglossal nerve palsy and on evaluation was diagnosed to have prostatic malignancy with metastasis to the base of skull. Unilateral hypoglossal nerve palsy as the presenting feature of carcinoma prostate is rarely des...

A bone scan was done and the findings were consistent with a diagnosis of Paget's disease in the right femur. It also revealed small areas of activity in the skull and pelvis. There was no evidence of pathological fracture, sarcomatous degeneration, or metastasis from prostate. It was concluded that pain was due to an increase in activity of the Pagetic lesion in the femur. The patient was put ...

Langerhans cell histiocytosis (LCH) usually occurs in children under the age of 10 years with a predilection for the skull, spine, rib and humerus. Solitary LCH occurring in an adult clavicle is uncommon with limited reports to date. The lesion in our patient was curetted with the intent to make a diagnosis, which subsequently lead to the remission of the symptom and the disease. At the final f...

A 12-year-old boy presented with primary Ewing's sarcoma of the occipital bone manifesting as intermittent high fever and local pain in the occipital region. Plain skull x-ray films disclosed an unclear lytic lesion in the occipital bone. Computed tomography and magnetic resonance imaging demonstrated the irregularly enhanced mass. The tumor was removed totally. He received intensive chemothera...

Neurofibromatosis type 1 is the most frequent phacomytosis. Patients with neurofibromatosis type 1 (NF1) have a high risk to develop benign or malignant tumors of neurogenic or non-neurogenic origin. The association of (NF1) to low-grade fibromyxoid sarcoma (LGFMS) is very rare. These tumors rarely develop at the skull and have a high incidence of local recurrence and distant metastasis. We rep...

BACKGROUND Head and neck adenoid cystic carcinoma (ACC) is a malignancy of the salivary and lacrimal glands with a variable growth pattern and propensity for perineural spread. Involvement of the skull base indicates a poor prognosis. Despite surgical resection and adjuvant radiotherapy, tumor recurrence and metastases are common. The urokinase-type plasminogen activator and its receptor (uPAR)...

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. It mainly occurs in patients with chronic diseases such as cirrhosis caused by hepatitis B or C infections, well alcoholics. HCC one highly malignant neoplasms. Extrahepatic metastases are seen 64% HCC, but to brain and skull extremely rare. Here, case a 45-year-old male who presented left III, IV, VI, IX, X, XII cr...

A 15 month old male child presented to the department of Paediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India, in February 2014, with complaints of fever, progressive pallor, abdominal mass and visible skull swelling (Fig. 1). X-ray of the skull (Fig. 2) raised the possibility of metastatic neuroblastoma. Other differential diagnoses included fibrous dysplasia, Ewing’s...