Arsenic poisoning is one of the major causes of chronic human illness and mortality in Bengal Delta plain with limited treatment options.The present study was conducted to evaluate the ameliorating effect of Glycosmis pentaphylla (Rutaceae) leaf extract against sodium arsenite (NaAsO2) induced toxicity. Forty eight adult albino rats were divided into four groups viz.,G0,G1,G2 and G3.Sodium arse...

Platelet-derived growth factor (PDGF), fibroblast growth factor, and heavy metal salts such as sodium arsenite stimulated BALB/c-3T3 cells to synthesize a 31-kDa protein(s) (termed p31) in a concentration-dependent manner. p31 was also synthesized in response to 12-O-tetradecanoylphorbol-13-acetate (TPA). V8 protease digestion of p31 purified from PDGF-, TPA-, and arsenite-treated cells showed ...

Inorganic arsenic exposure via drinking water has been associated with cancer and serious injury in various internal organs, as well as with peripheral neuropathy and diverse effects in the nervous system. Alterations in memory and attention processes have been reported in exposed children, whereas adults acutely exposed to high amounts of inorganic arsenic showed impairments in learning, memor...

The multidrug transporter, initially identified as a multidrug efflux pump responsible for resistance of cultured cells to natural product cytotoxic drugs, is normally expressed on the apical membranes of excretory epithelial cells in the liver, kidney, and intestine. This localization suggests that the multidrug transporter may have a normal physiological role in transporting cytotoxic compoun...

[This corrects the article DOI: 10.1155/2017/2597256.].

Heme oxygenase-1 (HO-1) gene expression is induced by various oxidative stress stimuli including sodium arsenite. Since mitogen-activated protein kinases (MAPKs) are involved in stress signaling we investigated the role of arsenite and MAPKs for HO-1 gene regulation in primary rat hepatocytes. The Jun N-terminal kinase (JNK) inhibitor SP600125 decreased sodium arsenite-mediated induction of HO-...

background: arsenic as an environmental toxicant is able to induced oxidative stress. the present study aimed to evaluate of vitamin c supplementation on the paraoxonase1 (pon1) arylesterase activity (responsible for hydrolysing lipid-peroxides) in rat exposed to arsenic. methods: the study was conducted in the faculty of veterinary medicine, tabriz islamic azad university, tabriz, iran in 2001...