In connection with the problem of the determination of the cardiac output by the use of ethylene (13), it seemed of interest to investigate further the nature of the forces which make the solubility of this gas 1% times as great in human blood as it is in water. The general problem of the nature of the factors which determine the solubility of gases in blood is of importance not only because of...

Understanding the solubility of nitrogen gas in tissues is a crucial aspect of diving physiology, especially for air-breathing tetrapods. Adipose tissue is of particular interest because of the high solubility of nitrogen in lipids. Surprisingly, nothing is known about nitrogen solubility in the blubber of any marine mammal. We tested the hypothesis that N(2) solubility is dependent on the lipi...

The solubility enhancement of diazepam and nitrazepam in water was analyzed depending on temperature and amount of α-cyclodextrin (α-CD), β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD). The interactions of drug-cyclodextrin in solution were investigated by the phase-solubility analysis. Diazepam (nitrazepam) content in aqueous complexation medium was analyzed UV spectropho...

Hydrocarbons are sparingly soluble in aqueous solvents and to a first approximation their solubility can be described by the traditional Henry’s Law, which linearly relates the mole fraction in water to gas-phase partial pressure. The presence of amines in the aqueous phase increases hydrocarbon solubility over that in water, an effect referred to as “salting-in”. Commercial amine treating solu...

Support Vector Machines (SVMs) are used to estimate aqueous solubility of organic compounds. A SVM equipped with a Tanimoto similarity kernel estimates solubility with accuracy comparable to results from other reported methods where the same data sets have been studied. Complete cross-validation on a diverse data set resulted in a root-mean-squared error = 0.62 and R(2) = 0.88. The data input t...

It is well documented that Pb solubility may be related to Fe chemistry in soils and enhanced Pb solubility may occur under certain reducing conditions; however, quantification of such relationships is unavailable. Based on metal classification, Pb (II) and Fe (II) are similar in some chemical characteristics. Thus, competition between Pb and Fe for ligands in soils may be important in determin...

Motivation Protein solubility is an important property in industrial and therapeutic applications. Prediction is a challenge, despite a growing understanding of the relevant physicochemical properties. Results Protein-Sol is a web server for predicting protein solubility. Using available data for Escherichia coli protein solubility in a cell-free expression system, 35 sequence-based propertie...

Lipid compounds are gaining increasing attention due to a wide range of applications in the food industry. Particularly, supercritical carbon dioxide (SCCO2) is being successfully employed as a green solvent in the extraction and fractionation of nonpolar lipids. Knowledge of the solubility of pure lipid-type substances and their mixtures in SCCO2 is essential for evaluating the viability of su...

In a paper from this laboratory, describing the dependence of the solubility of the plasma proteins in concentrated salt solutions on the salt and plasma concentrations (l), we pointed out the advantage of using potassium phosphate as a precipitating salt inasmuch as the salt concentration and pH of such solutions could be varied independently as described by Cohn (2). For the specific purpose ...

In a paper from this laboratory, describing the dependence of the solubility of the plasma proteins in concentrated salt solutions on the salt and plasma concentrations (l), we pointed out the advantage of using potassium phosphate as a precipitating salt inasmuch as the salt concentration and pH of such solutions could be varied independently as described by Cohn (2). For the specific purpose ...