We had extracted n-caproate from bioreactor broth. Here, we introduced in-line membrane electrolysis that utilized a pH gradient between two chambers to transfer the product into undissociated n-caproic acid without chemical addition. Due to the low maximum solubility of this acid, selective phase separation occurred, allowing simple product separation into an oily liquid containing ∼90% n-capr...

A brief history of solubility theory is outlined, and the distinguishing features of modern solubility theory are discussed. It is shown how the perturba— tion theory—based terms in the expression for the Henrys law constant provide microscopic information on covitation and solvation. Results are given both for atomic and molecular systems. In the case of atomic systems, where no adjustable par...

Cadmium sulfide particles were prepared by precipitation from acid solution. A radiotracer technique with 109Cd was applied tomeasure the solubili W of cadmium sulfide at various pH's. Filtration, centrifugation, ulttacentrifugation, and dialysis were used to separate the particles from the solution. Only the last two techniques proved to be successful. The solubility of cadmium sulfide in wate...

The solubility behaviour of drug is one of the most challenging aspects in formulation development. Thus a greater understanding of dissolution and absorption behaviour of drug with low aqueous solubility is required to successfully formulate them into more soluble and hence bioavailable drug product. Therefore different approaches are being explored to enhance the solubility of poorly water so...

Lamotrigine is used in the treatment of CNS disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. Lamotrigine belongs to biopharmaceutical classification systems, BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...

Isolation of mono-iodotyrosine from slightly iodinated pepsin has been repeated and the properties of the product compared with those of synthetic dl-3-iodotyrosine. Ultraviolet absorption spectra, pK values of the phenol group, solubility measurements, and partition coefficients were so nearly identical for the two materials that there is now no reason to doubt that the product from pepsin is ...