نتایج جستجو برای: somatic
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BACKGROUND The relationships among somatic complaints, emotion awareness and mood have been observed in late childhood and adolescence, but very few studies have been carried out in adult populations like this work. This study also incorporates personality dimensions that can exacerbate or reduce the emergence of somatic complaints. Therefore, the aim of this study is to analyse the combined co...
Somatic hypermutation and clonal selection lead to B cells expressing high-affinity antibodies. Here we show that somatic mutations not only play a critical role in antigen binding, they also affect the thermodynamic stability of the antibody molecule. Somatic mutations directly involved in antigen recognition by antibody 93F3, which binds a relatively small hapten, reduce the melting temperatu...
Somatic hypermutation (SHM) in immunoglobulin genes is required for high affinity antibody-antigen binding. Cultured cell systems, mouse model systems, and human genetic deficiencies have been the key players in identifying likely SHM pathways, whereas "pure" biochemical approaches have been far less prominent, but change appears imminent. Here we comment on how, when, and why biochemistry is l...
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