Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are two multifunctional peptides processed from a common precursor which have been described in numerous mammalian organs, including the pituitary gland. Previous studies have found AM immunoreactivity in neurohypophysis nerve fibers of amphibian pituitary. In the present study, immunocytochemical and Western blot analysis i...

The accurate partitioning of Firmicute plasmid pSM19035 at cell division depends on ATP binding and hydrolysis by homodimeric ATPase delta(2) (ParA) and binding of omega(2) (ParB) to its cognate parS DNA. The 1.83 A resolution crystal structure of delta(2) in a complex with non-hydrolyzable ATPgammaS reveals a unique ParA dimer assembly that permits nucleotide exchange without requiring dissoci...

Proteinases such as thrombin and trypsin can affect tissues by activating a novel family of G protein-coupled proteinase-activated receptors (PARs 1-4) by exposing a 'tethered' receptor-triggering ligand (TL). Work with synthetic TL-derived PAR peptide sequences (PAR-APs) that stimulate PARs 1, 2 and 4 has shown that PAR activation can play a role in many tissues, including the gastrointestinal...

Pseudo-Articulatory Representations (PARs) have been proposed and discussed in relation to speech processing with results reported for both synthesis and recognition. PARs are derived from linguistic specifications of articulatory activity which are both abstract and idealized. The abstractions and idealizations permit the linguistic generality to be distinguished from the articulatory reality;...

During systemic inflammation, recruitment and activation of leukocytes in the pulmonary microcirculation may result in a potentially life-threatening acute lung injury. We elucidated the role of the poly(ADP-ribose) synthetase (PARS), a nucleotide-polymerizing enzyme, in the regulation of leukocyte recruitment within the lung with regard to the localization in the pulmonary microcirculation and...

Gait and balance disturbances typically emerge in advanced Parkinson's disease with generally limited response to dopaminergic medication and subthalamic nucleus deep brain stimulation. Therefore, advanced programming with interleaved pulses was put forward to introduce concomittant nigral stimulation on caudal contacts of a subthalamic lead. Here, we hypothesized that the combined stimulation ...

During the refueling outage (RFO) 2013 at NPP Krško, electric hydrogen recombiners, a system for control during severe accidents and design basis accidents, were replaced by passive autocatalytic recombiners (PARs). next RFOs in 2015, 2016 2018, periodic tests of PAR cartridges performed. The testing NIS-PARs shall prove that catalytic reaction starts up as specified. According to licenced proc...

Pars distalis-extract treatment of intact or 'hypophysectomized' chicken embryos resulted in a splenomegaly, perhaps of a host-versus-graft nature, by 17 and 17-5 days of incubation. Pars distalis grafts in intact embryos reduced spleen size, encouraged white-pulp follicle formation, but 'suppressed' red-pulp development. Adult spleen extract and bovine serum albumin did not change spleen sizes...

1. Biosynthesis in the lead-haematoxylin positive pars intermedia cells of Sarotherodon mossambicus was analysed by SDS and acid-urea electrophoresis and high pressure liquid chromatography. 2. Pulse and pulse-chase experiments revealed that a non-glycosylated 30K-precursor was processed into a number of smaller products. 3. Melanotropic and endorphin-like peptides appeared to be the final prod...