We calculate the density-dependent spin-asymmetry energy S(kf ) of isospin-symmetric nuclear matter in the three-loop approximation of chiral perturbation theory. The interaction contributions to S(kf ) originate from one-pion exchange, iterated one-pion exchange, and (irreducible) two-pion exchange with no, single, and double virtual ∆-isobar excitation. We find that the truncation to 1π-excha...