Background Chlamydia trachomatis is a multifaceted, asymptomatic, most prevalent sexually transmitted pathogen worldwide. Due to lack of specific diagnostic methods for C. trachomatis in Spondyloarthropathy (SpA) patients, this pathogen is under diagnosed and under estimated in various countries including India. We aimed to estimate circulatory antibodies to chlamydial heat shock protein60 (chs...

The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls...

Introduction The role of gut inflammation and of intestinal permeability has been extensively studied in spondyloarthropathies, and more recently also in enthesitis–related arthritis (ERA). Clinical and experimental evidences have indicated that in genetically predisposed subjects alterations of gut microbiota may be linked to abnormal immune responses and chronic inflammatory disorders, and or...

Background: Spondyloarthropathies are a group of closely related inflammatory arthritis which involve the axial skeleton and are negative for rheumatoid factor. Objective: This case-control study was conducted to examine HLA- B27 positivity in patients with seronegative spondyloarthritis (SSA) as per ESSG criteria and compare the frequency with healthy controls because a lower positivity is rep...

Background The anti-inflammatory and immunosuppressive functions of kynurenic acid (KYNA) is in the center attention. Previously, we demonstrated effects KYNA analog on blood samples rheumatoid arthritis patients vitro. results showed suppression tumor necrosis factor-α (TNF-α), S100A12 (EN-RAGE), S100A8/9 (calprotectin) α-defensin production, with increase factor-stimulated gene-6 protein (TSG...

Spondyloarthritis is a group of diseases that seriously hampers quality of life. Diagnostic criteria, in which images play an important role, have evolved over time. The most recent diagnostic criteria, published in 2009, included magnetic resonance imaging (MRI) of the sacroiliac joints for the first time. This technique achieves an early diagnosis and provides a useful tool for the evaluation...

We have described a boy with a juvenile spondyloarthropathy who also showed inflammatory changes in the gut. Gastrointestinal symptoms initially indicated the presence of an inflammatory bowel disease, but this was excluded histopathologically.

Abstract Objective An intriguing link between gut and synovial inflammation exists in patients with spondyloarthropathy (SpA), illustrated by the high frequency of microscopically inflammatory gut lesions observed in these patients. We hypothesise that aberrant homing of mucosal T cells might play a role in the induction/perpetuation of arthritis in SpA. Here, we analyse the expression of the h...

Following the clinical observation of a peculiar joint pattern in children with Lyme arthritis, we classified the pattern of joint involvement in children with oligoarticular arthritis (2-4 joints) of different causes, including Lyme arthritis, juvenile chronic arthritis and juvenile spondyloarthropathy, as: (1) symmetrical: arthritis of the same joints on both sides of the body; (2) unilateral...

BACKGROUND Ankylosing enthesopathy (ANKENT) with progressive stiffening of ankle and tarsal joints of the hind limbs is a naturally occurring arthropathy in B10.BR mice. Some features are similar to those of the spondyloarthropathies in humans. OBJECTIVE To study the role of sexual dimorphism and testosterone in the development of ANKENT. METHODS The incidence of ANKENT was observed in non-...