Three monozygotic twin pairs, each over the age of 45 years, with ankylosing spondylitis are described. In two pairs there is discordance for this disease and in the third pair there is a marked difference in the severity of this disease. These findings provide evidence that environmental factors are necessary not only for the initial development of ankylosing spondylitis, but possibly also for...

OR (prognos*[Title/Abstract] OR (fi rst[Title/Abstract] AND episode[Title/Abstract]) OR cohort[Title/Abstract]))

INTRODUCTION Prevalence estimates of ankylosing spondylitis vary considerably, and there are few nationwide estimates. The present study aimed to describe the national prevalence of clinically diagnosed ankylosing spondylitis in Sweden, stratified according to age, sex, geographical, and socio-economic factors, and according to subgroups with ankylosing spondylitis-related clinical manifestatio...

conclusions: in this study, delay in diagnosis was similar to other studies. educating physicians to careful history taking especially in the case of ibp, non-musculoskeletal symptoms such as uveitis and precise physical examination are important in early diagnosis. patients and methods: sixty patients, (53 males, 7 females) with a diagnosis of as according to the modified new york criteria wer...

the human major histocompatibility complex (mhc) plays a crucial role in transplantation, transfusion, paternity test and assessment of susceptibility to some diseases associated with hla-b27. three of the most fashionable methods for determination of hla antigens in clinical and research laboratories are microlymphocytotoxicity (mlct), flowcytometry and polymerase chain reaction (pcr). the pur...