background colorectal cancer (crc) is one of the most common cancers worldwide which is not extensively researched in iran. objectives the present study aims to investigate the epidemiologic characteristics of crc in patients referred to selected hospitals of tehran university of medical sciences. patients and methods in this descriptive-analytic study 218 patients with colorectal cancer were i...

today’s knowledge on oesophageal adenocarcinoma and its rising incidence has encouraged researcher to illustrate relationship between barrett’s disease and progression to adenocarcinoma. the incidence of this disease has been accelerated sharply in current decades since people life has changed. studies have been demonstrated that several potential factors including genetical  and environmental ...

metastasis of gastroesphageal junction (gej) adenocarcinoma in skeletal muscle is rare and primary sites for skeletal muscle metastases are usually lung, renal and colorectal cancer. we have encountered with the first case report of solitary psoas muscle metastasis of gej adenocarcinoma. here we describe a 65 years old man was diagnosed with gej adenocarcinoma in tertiary hospital, tehran, iran...

Id1 and Id3 genes are required for vascularization, growth, and metastasis of xenograft tumors. In Id-deficient mice, tumor transplantation and proangiogenic factors fail to mobilize and recruit circulating endothelial precursor cells (CEPs) and hematopoietic cells, leading to defective tumor angiogenesis in various models. To investigate the requirement of Id genes and bone marrow incorporatio...

We report a direct comparison of the differential effects of individual p53 mutations on lung tumor growth and progression, and the creation of a murine model of spontaneous advanced lung adenocarcinoma that closely recapitulates several aspects of advanced human pulmonary adenocarcinoma. We generated compound conditional knock-in mice with mutations in K-ras combined with one of three p53 alle...

Indole-3-carbinol (I3C) present in cruciferous vegetables has been found to inhibit chemically induced neoplasms in forestomach, mammary gland, liver, and tongue in rodents. I3C is also known to induce estradiol 2-hydroxylase and reduce estrogenic activity. The current study was conducted to examine the possible inhibiting effect of I3C on spontaneous occurrence of endometrial adenocarcinoma in...

The macrophage content of spontaneous metastases has been quantified morphometrically for a panel of rodent tumors at different stages of metastatic tumor growth. Using a histochemical technique to selectively stain macrophages, we have evaluated the relative content of macrophages in spontaneous pulmonary metastases from the 13762NF MTLn3 rat mammary adenocarcinoma and the B16-BL6 mouse melano...