The primary activation of the epidermal growth factor receptor (EGFR) has become a prominent target for molecular therapies against several forms of cancer. But despite considerable progress during the last years, many of its aspects remain poorly understood. Experiments on lateral spreading of receptor activity into ligand-free regions challenge the current standard models of EGFR activation. ...

This paper demonstrates the utility of the Semantic Network Array Processor (SNAP) as a massively parallel platform for high performance and large-scale natural language processing systems. SNAP is an experimental massively parallel machine which is dedicated to, but not limited to, the natural language processing using semantic networks. In designing the SNAP, we have investigated various natu...

Semantic priming involves a combination of automatic processes like spreading activation (SA) and controlled processes like expectancy and semantic matching. An alternative account for automatic priming has been suggested using attractor neural networks. Such networks offer a more biologically plausible model of real neuronal dynamics but fall short in explaining several important effects such ...

This study examined whether processing ambiguous sentences containing relative clauses (RCs) following a complex determiner phrase (DP) by Persian-speaking learners of L2 English with different proficiency and working memory capacities (WMCs) is affected by semantic priming. The semantic relationship studied was one between the subject/verb of the main clause and one of the DPs in the complex D...

In this chapter we aim to establish a set of requirements for the design and implementation of models for sustaining dialogue in Intelligent Tutoring Systems, which incorporate mechanisms for negotiating cooperative teaching and learning goals. Our discussion is centred around a first prototype computational model called "KANT"`(Kritical Argument Negotiated Tutoring system), which incorporates ...

Mixed-initiative interaction (MII) plays an important role in conversation agent. In the former MII research, MII process only static conversation and cannot change the conversation topic dynamically by the system because the agent depends only on the working memory and predefined methodology. In this paper, we propose the mixed-initiative interaction based on human cognitive architecture and m...

We evaluate a wide range of recommendation algorithms on e-commerce-related datasets. These algorithms include the popular user-based and item-based correlation/similarity algorithms as well as methods designed to work with sparse transactional data. Data sparsity poses a significant challenge to recommendation approaches when applied in ecommerce applications. We experimented with approaches s...

A computer system for analyzing and generating improvisational jazz solos is currently under development. I maintain that an enumeration and quantification of musical common sense concepts is necessary for the construction of musically intelligent systems. My design of an architecture to organize and manipulate musical knowledge is influenced by the agent-based approach of [Minsky 86], and the ...

Spreading activation, in the farm of computer models and cognitive theories, has recently been undergoing a resurgence of interest in the cognitive science and Al communities. Two different types of cognitive models have been proposed to explain the activation spreading results. One approach, that of marker-passing, concentrates on the spreading of symbolic information through an associative kn...