نتایج جستجو برای: spreading depolarization
تعداد نتایج: 47219 فیلتر نتایج به سال:
There is increasing evidence in the experimental and clinical traumatic brain injury (TBI) literature that loss of central myelinated nerve fibers continues over the chronic post-traumatic phase after injury. However, the biomechanism(s) of continued loss of axons is obscure. Stretch-injury to optic nerve fibers in adult guinea-pigs was used to test the hypothesis that damage to the myelin shea...
The term spreading depolarization (SD) refers to waves of abrupt, sustained mass depolarization in gray matter of the CNS. SD, which spreads from neuron to neuron in affected tissue, is characterized by a rapid near-breakdown of the neuronal transmembrane ion gradients. SD can be induced by hypoxic conditions--such as from ischemia--and facilitates neuronal death in energy-compromised tissue. S...
UNLABELLED Spreading depolarizations (SDs) are recognized as actors in neurological disorders as diverse as migraine and traumatic brain injury (TBI). Migraine aura involves sensory percepts, suggesting that sensory cortices might be intrinsically susceptible to SDs. We used optical imaging, MRI, and field potential and potassium electrode recordings in mice and electrocorticographic recordings...
Aiba I, Carlson AP, Sheline CT, Shuttleworth CW. Synaptic release and extracellular actions of Zn limit propagation of spreading depression and related events in vitro and in vivo. J Neurophysiol 107: 1032–1041, 2012. First published November 30, 2011; doi:10.1152/jn.00453.2011.—Cortical spreading depression (CSD) is a consequence of a slowly propagating wave of neuronal and glial depolarizatio...
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