Background: A major problem arising from searching across bibliographic databases is the retrieval of duplicate citations. Removing such duplicates is an essential task to ensure systematic reviewers do not waste time screening the same citation multiple times. Although reference management software use algorithms to remove duplicate records, this is only partially successful and necessitates r...

BACKGROUND Estimates of body-composition change in older adults are mostly derived from cross-sectional data. OBJECTIVE We examined the natural longitudinal patterns of change in fat-free mass (FFM) and fat mass (FM) in older adults and explored the effect of physical activity, weight change, and age on these changes. DESIGN The body composition measured by hydrodensitometry and the level o...

Macrophage death in advanced atherosclerosis promotes necrosis and plaque destabilization. A likely cause of macrophage death is accumulation of free cholesterol (FC) in the ER, leading to activation of the unfolded protein response (UPR) and C/EBP homologous protein (CHOP)-induced apoptosis. Here we show that p38 MAPK signaling is necessary for CHOP induction and apoptosis. Additionally, two o...

[14C]-Serotonin release assay (14C-SRA) from platelets is considered to be the most sensitive test for laboratory confirmation of heparin-induced thrombocytopenia (HIT). This study compared 14C-SRA with an enzyme immunoassay (EIA) to determine the release of serotonin from platelets in the presence of heparin and serum from HIT patients. The normal range (median, 2.5 and 97.5 percentiles) of se...

Penetapan Sekolah Ramah Anak (SRA) pada suatu sekolah dilakukan melalui dua tahap yaitu persiapan dan perencanaan, kemudian dilanjutkan dengan pembentukan pengembangan. Berdasarkan Panduan Anak, pengembangan verifikasi terhadap enam komponen, salah satunya adalah komponen kebijakan SRA. Menurut penulis, proses penetapan SRA bersifat dinamis, sehingga tidak cukup jika hanya saja. Agar asesmen da...

Context: Software Reference Architectures (SRAs) play a fundamental role for organizations whose business greatly depends on the efficient development and maintenance of complex software applications. However, little is known about the real value and risks associated with SRAs in industrial practice. Objective: To investigate the current industrial practice of SRAs in a single company from the ...

BACKGROUND Osteopontin (OPN) is a glycoprotein that has been associated with inflammation and fibrosis. Severe refractory asthma (SRA) is characterised by an intense inflammatory and remodelling process. The aim of this study was to investigate the levels of OPN in sputum supernatants of patients with SRA, to compare them with milder forms of the disease and to investigate their possible associ...

BACKGROUND Body composition is an important parameter for patients with chronic obstructive pulmonary disease (COPD) whereas the association between asthma and obesity is not fully understood. The impact of severe refractory asthma (SRA) on fat free mass (FFM) has not been investigated. METHODOLOGY AND PRINCIPAL FINDINGS 213 subjects (70 healthy smokers, 71 COPD patients and 72 asthma patient...

BACKGROUND There are many systemic complications of conventional selective renal arteriography (SRA), such as contrast-mediated nephropathy. Contrast-enhanced magnetic resonance angiography (CE-MRA) and renal artery Doppler ultrasonography (DUSG) have been used increasingly for renal artery stenosis (RAS). The aim of this study was to evaluate the accuracy of CE-MRA and DUSG as used for diagnos...