OBJECTIVE To explore the impact of statin use on cognition. DATA SOURCES A literature search was performed using MEDLINE (1950-November 2011), EMBASE (1980-November 2011), and the Cochrane Library (1960-November 2011) using the search terms "cognition/drug effects," "delirium, dementia, amnestic, cognitive disorders/chemically induced," "memory disorders/chemically induced," "hydroxymethylglu...

we estimate that there are more than 100000 patients presently on statin treatment, and that about 10% of these patients will also be on long-term warfarin therapy. I believe your Editorial was correct in highlighting the issue of safety, and to suggest that “physicians must tell their patients the truth about rosuvastatin”. However, I would add that physicians themselves should be informed of ...

Lowering low-density lipoproteins (LDL) by statin therapy to reduce the risk for major clinical events in patients with established atherosclerotic cardiovascular disease (ASCVD) represents a therapeutic triumph of modern medicine. With standard doses of statins, the risk for CVD events falls by approximately one third.1 Additional risk reduction occurs by adding other therapeutic modalities to...

Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, however, possible interactions with other drugs deserve particular attention, as many patients ...

To the Editor: The cholesterol-lowering statin drugs are contraindicated in pregnancy1; therefore, few data exist regarding their safety in human gestation. We reviewed 178 cases of first-trimester statin exposure reported to the Food and Drug Administration (FDA) from 1987 through 2001 for patterns suggesting possible drug-related effects on embryogenesis. After the exclusion of cases involvin...

Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, however, possible interactions with other drugs deserve particular attention, as many patients ...

S tatin treatment is a safe and effective method of reducing cardiovascular events in both primary and secondary prevention. 2 Persistence with statin use in trials is generally high. Analysis of the WOSCOPS (west of Scotland coronary prevention study) showed that the efficacy of pravastatin depends on compliance. Although long term persistence with statin treatment in elderly patients has been...

The lipid-lowering actions of statins are well known. However, recent studies provide compelling evidence that the clinical benefits of statin therapy may also be attributed to mechanisms independent of their cholesterol-lowering effects. These non-lipid-lowering (pleiotropic) effects of statin therapy are believed to include antiinflammatory actions, property to reverse endothelial dysfunction...

1172 NEWS Journal of the National Cancer Institute, Vol. 97, No. 16, August 17, 2005 Statins grabbed the headlines earlier this year when several epidemiologic studies produced promising results that the cholesterol-lowering drugs might be associated with reduced risks of several cancers, including breast, colorectal, lung, and prostate cancers. Although some researchers have called for large r...