A number of cytotoxic drugs (mitotic poisons, chemical mutagens, bifunctional alkylating agents, inhibitors of DNA, RNA, or protein synthesis, for a total of 18 agents) have been tested for differences in their lethal effects through the generation cycle of HeLa and Chinese ham ster cells in culture. The patterns of age response of cells to each group of agents show some features in common: mit...

In this paper functional maturity of mammary epithelium will be defined as the capacity of the cells to secrete, and it may be determined by a simple method—by the production of milk fol lowing the administration of luteotrophin. It is known that functional maturity of the breast is never achieved in the absence of appropriate hormones or artificial substances with a similar physiologic activ...

NOTES 2.0 – How Japan and China are taking over the (endoscopic) world. About ten years after the first hype, natural orifice translumenal endoscopic surgery (NOTES) has become part of endoscopic routine. Transmural necrosectomy, for example, is an important technique among minimal invasive treatment options for acute necrotizing pancreatitis. In Japan and China, “peroral endoscopic myotomy“ (P...

We have developed a qualitative and quantitative assay system for detecting cells lacking postconfluence inhibition of cell division (contact insensitivity, CS~) in golden Syrian ham ster embryo cells in culture by measuring the number of cells able to form colonies on a lethally irradiated, confluent monolayer of a contact-sensitive established cell line. A subpopulation in normal low-passage ...

The Sloan Digital Sky Survey is an ambitious, multi-institutional project to create a huge digital imaging and spectroscopic data bank of 25% of the celestial sphere, approximately 10,000 deg2 centred on the north galactic polar cap. The photometric atlas will be in 5 specially-chosen colours, covering the π ster of the Survey area to a limiting magnitude of r∼23.1, on 0 . 4 pixels, resulting i...

Receptors for insulin and epidermal growth factor-urogastrone (EGF-URO) have been measured in Syrian hamster em bryo fibroblasts and in a benzo(a)pyrene-transformed tumorigenie cell line (BP6T). Compared with the parent Syrian ham ster embryo cells, the BP6T cells exhibit a marked reduction in the binding of EGF-URO, whereas the binding of insulin is the same in both cell types. The selective r...

The Sloan Digital Sky Survey is an ambitious, multi-institutional project to create a huge digital imaging and spectroscopic data bank of 25% of the celestial sphere, approximately 10,000 deg2 centred on the north galactic polar cap. The photometric atlas will be in 5 specially-chosen colours, covering the π ster of the Survey area to a limiting magnitude of r′∼23.1, on 0′′ . 4 pixels, resultin...

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