central granular cell odontogenic tumor) cgcot) of the jaw is an exceedingly rare benign odontogenic neoplasm with 35 reported cases in the literature. among these, very few studies have focused on the cone-beam ct features of cgcot. here, we report a case of an asymptomatic cgcot in a 16-year-old girl and focus on the cone-beam ct features. only 36 cases of this lesion, including this one, hav...

congenital granular cell tumor (cgct) is a unique benign tumor of soft tissue in newborns, which usually occurs on the anterior alveolar mucosa of the jaws. it is 8 to 10 times more prevalent in females than males. we present a case report of a 3-month-old female infant, who had a solitary mass on the anterior mandibular alveolar ridge. the lesion, which was histologically a congenital granular...

introduction: complete androgen insensitivity syndrome (previously called testicular feminization) is specified by a 46 xy karyotype and negative sex chromatin, bilateral undescended testes, female genitalia appearance, and lack of mullerian derivatives. discussion: our medline search revealed that this is the first reported case of bilateral sertoli–leydig cell tumor (slct) in androgen insensi...

desmoplastic small round cell tumor (dscrt) is a rare variant of sarcoma with a highly aggressive behavior. it usually affects abdominal cavity and has a male predominance. its correct diagnosis and treatment is sophisticated and requires an experienced multidisciplinary team. hereby we present a 25 yrold man from kerman province in 2013 with abdominal mass and ascites who underwent sonograghy ...

PURPOSE The aromatase inhibitors letrozole and anastrozole have been approvedrecently as first-line treatment options for hormone-dependent advanced breast cancer. Although it is established that a proportion of patients who relapse on first-line tamoxifen therapy show additional responses to aromatase inhibitors, it has not been determined whether tumors that acquire resistance to aromatase in...

introduction: the aim of this study was to investigate the effect of the hsp-70 (heat shock protein-70) induction in the lysate of heat shocked tumor cells on splenocyte proliferation, nitric oxide production by peritoneal macrophages, and fibrosarcoma tumor size reduction in balb/c mice. material and methods: wehi 164 cells (mouse fibrosarcoma cell line) were injected subcutaneously into the r...

Abstract INTRODUCTION Immune therapeutic strategies are ideal for exploiting glial tumor heterogeneity. A limitation to their implementation intra-axial brain tumors has been corticosteroids. Steroid use is associated with worse progression-free and overall survival when combined some immunotherapies. Dexamethasone remains first line treatment vasogenic cerebral edema a primary therapy immune-r...

The GALN gene encodes the preprogalanin protein that is cleaved to liberate the galanin peptide, a neuropeptide and tumor cell mitogen, and the galanin message-associated peptide, which is of unknown function. GALN is located at chromosome 11q13, a frequently amplified locus in diverse tumor types including breast cancer. To determine whether GALN may contribute to the tumor phenotype resulting...

background and aims: plants as medicines have always played a vital role in human life. tumor necrosis factor alpha (tnf)-α is one of the macrophage-derived inflammatory cytokine with pleotropic effects in the inflammation process. some studies have been demonstrated that some of the echinops species have anti-inflammatory activity. in fact, echinops lasilepis is introduced as one of the native...

objective: recent evidences suggest that tumors arise from a small subpopulation of cells, the cancer stem cells (cscs) or tumor initiating cells. cscs are able to resist the conventional methods of cancer therapy due to existence of abc transporters on their surface. this leads to csc resistance and maintenance resulting in post-treatment relapse and metastasis. therefore, precise identificati...