OBJECTIVE This study aimed to investigate the long-term outcomes in children with steroid-resistant nephrotic syndrome (SRNS), who received methylprednisolone pulse therapy (MPT)-based sequential steroid therapy. In particular, we aimed to observe whether these patients had a high risk of adverse events. METHODS We conducted a retrospective study over a 5-year period. The long-term outcomes f...

OBJECTIVE A wide mucosal defect after endoscopic submucosal dissection (ESD) for esophageal cancer is associated with increased risk of stricture. This study was conducted to evaluate the feasibility of short-period, high-dose intravenous methylprednisolone administration (steroid pulse therapy) in preventing post-ESD esophageal stricture. METHODS This prospective study examined 13 lesions in...

BACKGROUND Churg-Strauss syndrome (CSS) is a rare granulomatous small vessel vasculitis that occurs against a background of longstanding asthma. Leukotriene antagonists (LTAs) are used in the management of asthma and may facilitate a reduction in steroid dosage. Reports of the development of CSS in patients with asthma following the initiation of LTA therapy suggest either a causal association ...

Numerous cases of osteonecrosis associated with steroid therapy have been reported and most of these had received large doses for prolonged periods. Avascular necrosis of bone occurring after short term steroid treatment is, however, rare. Many underlying causes have been suggested as being associated with this condition. Gregg et al believe that cases may have avascular necrosis of bone with c...

To overcome this, a simple modification can be made so that even in illuminated rooms this instrument can That strongyloidiasis should be excluded before initiating immunosuppressive therapy is widely known. In Indian leprosy manuals, strongyloidiasis is mentioned as a contraindication for steroid therapy in patients of leprosy. However, the fact that strongyloidiasis should be treated before i...

RATIONALE We report a case of acute steroid myopathy in a patient with eczema receiving one dose of intra-muscular injection of Compound betamethasone. PATIENT CONCERNS Acute steroid myopathy (ASM) is usually caused by exogenous corticosteroids, and typically, occurs with therapy using intravenous corticosteroids at high doses. DIAGNOSES The patient was considered as a diagnosis of acute st...

Corticosteroid administration has been widely used as the empirical treatment for various inner ear diseases such as sudden sensorineural hearing loss (SNHL), Meniere disease, and autoimmune-induced hearing loss for a long time. After Sakata et al. [1] first tried intratympanic (IT) steroid injection to control Meniere disease, IT steroid injection treatment has been used as an alternative opti...

Background: Alopecia areata is a common disorder of hair occurring on any hair bearing site of the body and having a great psychosocial impact. Aims: To assess the demographic pattern, clinical aspects, associations and therapeutic response of AA in a tertiary care teaching hospital. Materials & methods: All patients diagnosed with alopecia areata were included in the study. With due consent, t...

BACKGROUND AND OBJECTIVES Few well-designed investigations have examined how tonsillectomy plus steroid pulse therapy affects IgA nephropathy. A prospective, controlled study therefore was performed to compare the effects of combined therapy with those of steroid pulse alone in patients with IgA nephropathy. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Fifty-five patients were followed up fo...

Background Granulocyte-monocyte apheresis has been proposed for the treatment of ulcerative colitis, although it is limited by costs and variability of results. Aim To assess effectiveness of granulocyte-monocyte apheresis in patients with steroid-dependent, azathioprine-intolerant/resistant moderate ulcerative colitis. Methods Consecutive patients fulfilling inclusion criteria were prospec...